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Mouse Anti-USP1 Recombinant Antibody (CF466) (CBMAB-FT055LY)

The product is antibody recognizes USP1 . The antibody CF466 immunoassay techniques such as: ELISA, WB, IHC.
See all USP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF466
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Immunogen
ubiquitin specific peptidase 1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 1
Introduction
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
7398
UniProt ID
O94782
Alternative Names
Deubiquitinating enzyme 1, hUBP, ubiquitin specific peptidase 1, Ubiquitin thiolesterase 1, UBP, USP1
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Biological Process
Biological Process DNA repair Source:UniProtKB-KW
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of error-prone translesion synthesis Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:UniProtKB1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
PTM
Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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