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Mouse Anti-USP4 Recombinant Antibody (5E12) (CBMAB-U0094-CQ)

This product is a mouse antibody that recognizes USP4. The antibody 5E12 can be used for immunoassay techniques such as: ELISA, WB.
See all USP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E12
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin specific peptidase 4 (proto-oncogene)
Introduction
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21.
Entrez Gene ID
7375
UniProt ID
Q13107
Alternative Names
UNP; Unph
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766).
Deubiquitinates PDPK1 (PubMed:22347420).
Deubiquitinates TRIM21 (PubMed:16316627).
Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847).
Deubiquitinates HAS2 (PubMed:28604766).
May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234).
This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234).
May also play a role in the regulation of quality control in the ER (PubMed:16339847).
Biological Process
Biological Process negative regulation of protein ubiquitination Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB3 Publications
Biological Process protein localization to cell surface Source:UniProtKB1 Publication
Biological Process regulation of protein stability Source:UniProtKB1 Publication
Biological Process spliceosomal tri-snRNP complex assembly Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm
Nucleus
Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
PTM
Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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