Rabbit Anti-USP4 Recombinant Antibody (CBXU-021) (CBMAB-U0137-CQ)

Name: Rabbit Anti-USP4 Recombinant Antibody (CBXU-021)
SKU: CBMAB-U0137-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

CBXU-021

Application

WB, ICC

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ubiquitin specific peptidase 4 (proto-oncogene)

Introduction

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21.

Entrez Gene ID

7375

UniProt ID

Q13107

Alternative Names

UNP; Unph

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766).
Deubiquitinates PDPK1 (PubMed:22347420).
Deubiquitinates TRIM21 (PubMed:16316627).
Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847).
Deubiquitinates HAS2 (PubMed:28604766).
May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234).
This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234).
May also play a role in the regulation of quality control in the ER (PubMed:16339847).

Biological Process

Biological Process negative regulation of protein ubiquitination Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB3 Publications
Biological Process protein localization to cell surface Source:UniProtKB1 Publication
Biological Process regulation of protein stability Source:UniProtKB1 Publication
Biological Process spliceosomal tri-snRNP complex assembly Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm
Nucleus
Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.

PTM

Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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