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Mouse Anti-VAMP5 Recombinant Antibody (3D4) (CBMAB-A9851-LY)

The product is antibody recognizes VAMP5. The antibody 3D4 immunoassay techniques such as: WB, ELISA.
See all VAMP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
VAMP5 (NP_006625, 1 a.a. ~ 70 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
vesicle-associated membrane protein 5 (myobrevin)
Introduction
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq]
Entrez Gene ID
10791
UniProt ID
O95183
Function
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process Golgi to plasma membrane protein transport Source:GO_Central1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process skeletal muscle tissue development Source:Ensembl
Cellular Location
Cell membrane
Endomembrane system
Golgi apparatus, trans-Golgi network membrane
Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).
Topology
Cytoplasmic: 1-72
Helical: 73-93
Vesicular: 94-116
PTM
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820).
It remains unknown whether BoNT/X is ever produced, or what organisms it targets.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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