VAMP5

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq]

Full Name

vesicle-associated membrane protein 5 (myobrevin)

Function

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

Biological Process

Biological Process cell differentiation Source:UniProtKB-KW
Biological Process Golgi to plasma membrane protein transport Source:GO_Central1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process skeletal muscle tissue development Source:Ensembl

Cellular Location

Cell membrane
Endomembrane system
Golgi apparatus, trans-Golgi network membrane
Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).

Topology

Cytoplasmic: 1-72
Helical: 73-93
Vesicular: 94-116

PTM

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820).
It remains unknown whether BoNT/X is ever produced, or what organisms it targets.