Mouse Anti-VLDLR Monoclonal Antibody (1H10) (CBMAB-1713-YC)

Name: Mouse Anti-VLDLR Monoclonal Antibody (1H10)
SKU: CBMAB-1713-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1H10

Application

ELISA, FC, WB

Immunogen

Synthetic peptide from the C-terminal region of Human VLDL Receptor

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Very Low Density Lipoprotein Receptor

Introduction

VLDLR is a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia.

Entrez Gene ID

Human	7436
Mouse	22359

UniProt ID

Human	P98155
Mouse	P98156

Alternative Names

CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH

Function

Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003).
In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003).
Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003).
This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).

Biological Process

Biological Process cholesterol metabolic process Source:UniProtKB-KW
Biological Process dendrite morphogenesis Source:Ensembl
Biological Process glycoprotein transport Source:BHF-UCL1 Publication
Biological Process lipid transport Source:UniProtKB-KW
Biological Process memory Source:ProtInc1 Publication
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process positive regulation of dendrite development Source:BHF-UCL
Biological Process positive regulation of protein kinase activity Source:Ensembl
Biological Process receptor-mediated endocytosis Source:BHF-UCL1 Publication
Biological Process reelin-mediated signaling pathway Source:BHF-UCL
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process ventral spinal cord development Source:Ensembl
Biological Process very-low-density lipoprotein particle clearance Source:BHF-UCL1 Publication

Cellular Location

Cell membrane
Membrane, clathrin-coated pit

Involvement in disease

Cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1 (CAMRQ1):
An autosomal recessive, congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, intellectual disability, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures.

Topology

Extracellular: 28-797
Helical: 798-819
Cytoplasmic: 820-873

PTM

Ubiquitinated at Lys-839 by MYLIP leading to degradation.
Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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