Human Recombinant VLDLR protein, His Tag-1 (V2LY-0526-LY7634)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003).
Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003).
This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Biological Process dendrite morphogenesis Source:Ensembl
Biological Process glycoprotein transport Source:BHF-UCL1 Publication
Biological Process lipid transport Source:UniProtKB-KW
Biological Process memory Source:ProtInc1 Publication
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process positive regulation of dendrite development Source:BHF-UCL
Biological Process positive regulation of protein kinase activity Source:Ensembl
Biological Process receptor-mediated endocytosis Source:BHF-UCL1 Publication
Biological Process reelin-mediated signaling pathway Source:BHF-UCL
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process ventral spinal cord development Source:Ensembl
Biological Process very-low-density lipoprotein particle clearance Source:BHF-UCL1 Publication
Membrane, clathrin-coated pit
An autosomal recessive, congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, intellectual disability, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures.
Helical: 798-819
Cytoplasmic: 820-873
Glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant VLDLR protein, His Tag (CAT#: V2LY-0526-LY7633)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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