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Mouse Anti-VLDLR Recombinant Antibody (VLDLR/1337) (CBMAB-V0080-LY)

This product is antibody recognizes VLDLR. The antibody VLDLR/1337 immunoassay techniques such as: WB, FC, IHC-P, IF.
See all VLDLR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
VLDLR/1337
Antibody Isotype
IgG1
Application
WB, FC, IHC-P, IF

Basic Information

Immunogen
Recombinant human VLDLR fragment from c-terminal (exact sequence is proprietary)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Very Low Density Lipoprotein Receptor
Introduction
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
Entrez Gene ID
7436
UniProt ID
P98155
Alternative Names
Very Low Density Lipoprotein Receptor; VLDL Receptor; VLDL-R; Very Low-Density Lipoprotein Receptor; VLDLRCH; CAMRQ1; CARMQ1; CHRMQ1;
Function
Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003).
In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003).
Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003).
This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Biological Process
Biological Process cholesterol metabolic process Source:UniProtKB-KW
Biological Process dendrite morphogenesis Source:Ensembl
Biological Process glycoprotein transport Source:BHF-UCL1 Publication
Biological Process lipid transport Source:UniProtKB-KW
Biological Process memory Source:ProtInc1 Publication
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process positive regulation of dendrite development Source:BHF-UCL
Biological Process positive regulation of protein kinase activity Source:Ensembl
Biological Process receptor-mediated endocytosis Source:BHF-UCL1 Publication
Biological Process reelin-mediated signaling pathway Source:BHF-UCL
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process ventral spinal cord development Source:Ensembl
Biological Process very-low-density lipoprotein particle clearance Source:BHF-UCL1 Publication
Cellular Location
Cell membrane
Membrane, clathrin-coated pit
Involvement in disease
Cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1 (CAMRQ1):
An autosomal recessive, congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, intellectual disability, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures.
Topology
Extracellular: 28-797
Helical: 798-819
Cytoplasmic: 820-873
PTM
Ubiquitinated at Lys-839 by MYLIP leading to degradation.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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