Mouse Anti-WAS Recombinant Antibody (CBYY-1587) (CBMAB-1657-YY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410).
Possible regulator of lymphocyte and platelet function (PubMed:9405671).
Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809).
In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068).
Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Actin filament-based movement
Actin polymerization or depolymerization
Blood coagulation
Cdc42 protein signal transduction
Cellular response to type II interferon
Defense response
Endosomal transport
Epidermis development
Immune response
Negative regulation of cell motility
Negative regulation of stress fiber assembly
Positive regulation of double-strand break repair via homologous recombination
Positive regulation of transcription by RNA polymerase II
Protein-containing complex assembly
Regulation of actin polymerization or depolymerization
Regulation of lamellipodium assembly
Regulation of stress fiber assembly
Regulation of T cell antigen processing and presentation
T cell activation
Nucleus
An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.
Thrombocytopenia 1 (THC1):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
Neutropenia, severe congenital, X-linked (XLN):
A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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