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Mouse Anti-WAS Recombinant Antibody (CBYY-1617) (CBMAB-1688-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1617
Antibody Isotype
IgG2a
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WASP actin nucleation promoting factor
Entrez Gene ID
7454
UniProt ID
P42768
Research Area
Signal Transduction
Function
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905).
Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410).
Possible regulator of lymphocyte and platelet function (PubMed:9405671).
Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809).
In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068).
Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Biological Process
Actin filament polymerization
Actin filament-based movement
Actin polymerization or depolymerization
Blood coagulation
Cdc42 protein signal transduction
Cellular response to type II interferon
Defense response
Endosomal transport
Epidermis development
Immune response
Negative regulation of cell motility
Negative regulation of stress fiber assembly
Positive regulation of double-strand break repair via homologous recombination
Positive regulation of transcription by RNA polymerase II
Protein-containing complex assembly
Regulation of actin polymerization or depolymerization
Regulation of lamellipodium assembly
Regulation of stress fiber assembly
Regulation of T cell antigen processing and presentation
T cell activation
Cellular Location
Cytoplasm, cytoskeleton
Nucleus
Involvement in disease
Wiskott-Aldrich syndrome (WAS):
An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.
Thrombocytopenia 1 (THC1):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
Neutropenia, severe congenital, X-linked (XLN):
A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
PTM
Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.
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For research use only. Not intended for any clinical use.

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