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Mouse Anti-WDR83 Recombinant Antibody (4E12) (CBMAB-W0113-WJ)

This product is a mouse antibody that recognizes WDR83. The antibody 4E12 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all WDR83 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E12
Antibody Isotype
IgG2a, к
Application
ELISA, IF, WB

Basic Information

Immunogen
MORG1 (NP_115708, aa171-262) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: VDGRVRRYDL RMGQLFSDYV GSPITCTCFS RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV VSCSEDGKVF FW
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD REPEAT DOMAIN 83
Introduction
WDR83 is a protein-coding gene encodes a member of the WD-40 protein family which is proposed to function as a molecular scaffold for various multimeric protein complexes. Among its related pathways are RET signaling and Cytokine Signaling in Immune system Gene. An important paralog of this gene is ATG16L2.
Entrez Gene ID
84292
UniProt ID
Q9BRX9
Alternative Names
MORG1
Function
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity).
May also be involved in pre-mRNA splicing.
Biological Process
Biological Process inflammatory response to wounding Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic. Partially nuclear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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