Mouse Anti-WDR83 (AA 171-263) Recombinant Antibody (CBFYM-3182) (CBMAB-M3379-FY)

Name: Mouse Anti-WDR83 (AA 171-263) Recombinant Antibody (CBFYM-3182)
SKU: CBMAB-M3379-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYM-3182

Application

ELISA, WB

Immunogen

Recombinant corresponding to aa171-263 from human MORG1 (NP_115708) with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 171-263

More Infomation

Target

Full Name

WD REPEAT DOMAIN 83

Introduction

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

84292

UniProt ID

Q9BRX9

Alternative Names

WD Repeat Domain 83; MAPK Organizer 1; Mitogen-Activated Protein Kinase Organizer 1; MORG1; WD Repeat Domain-Containing Protein 83

Function

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity).
May also be involved in pre-mRNA splicing.

Biological Process

Biological Process inflammatory response to wounding Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic. Partially nuclear.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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