WDR83

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

Full Name

WD REPEAT DOMAIN 83

Function

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity).
May also be involved in pre-mRNA splicing.

Biological Process

Biological Process inflammatory response to wounding Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic. Partially nuclear.