Mouse Anti-XPNPEP2 Recombinant Antibody (CBYC-A1093) (CBMAB-A4944-YC)

Name: Mouse Anti-XPNPEP2 Recombinant Antibody (CBYC-A1093)
SKU: CBMAB-A4944-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYC-A1093

Application

WB, IP, Neut

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Aminopeptidase P2/XPNPEP2, His22-Ala650.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

X-Prolyl Aminopeptidase 2

Introduction

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occ

Entrez Gene ID

7512

UniProt ID

O43895

Alternative Names

X-Prolyl Aminopeptidase 2; X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound; Aminoacylproline Aminopeptidase; AEACEI; APP2; EC 3.4.11.9

Function

Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.

Biological Process

Biological Process proteolysis Source:UniProtKB-KW

Cellular Location

Cell membrane

Involvement in disease

Angioedema induced by ACE inhibitors (AEACEI):
A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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