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Mouse Anti-XRN2 Recombinant Antibody (CBT3026) (V2LY-0625-LY495)


See all XRN2 antibodies
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3026
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Purified recombinant fragment of human XRN2 (AA: 398-547) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5'-3' Exoribonuclease 2
Entrez Gene ID
22803
Function
Possesses 5'->3' exoribonuclease activity (By similarity).
May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
Biological Process
Biological Process DNA catabolic process, exonucleolytic Source:UniProtKB1 Publication
Biological Process hippocampus development Source:Ensembl
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process neuron differentiation Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process Source:GO_Central1 Publication
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process RNA catabolic process Source:ProtInc1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process RNA processing Source:ProtInc1 Publication
Biological Process rRNA processing Source:Reactome
Biological Process spermatogenesis Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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