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Rabbit Anti-XRN2 Recombinant Antibody (D6L5F) (CBMAB-X0250-YC)

Provided herein is a Rabbit monoclonal antibody against Human XRN2. The antibody, clone D6L5F, can be used for immunoassay techniques, such as WB, IP.
See all XRN2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D6L5F
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5'-3' Exoribonuclease 2
Introduction
XRN2 is a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. XRN2 binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites. XRN2 may promote the termination of transcription by RNA polymerase II.
Entrez Gene ID
Human22803
Mouse24128
Rat362229
Monkey700934
UniProt ID
HumanQ9H0D6
MouseQ9DBR1
RatD4A914
MonkeyH9FRE3
Alternative Names
5'-3' exoribonuclease 2; DHP protein; Dhm1-like protein; EC 3.1.13.-
Function
Possesses 5'->3' exoribonuclease activity (By similarity).
May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
Biological Process
Biological Process DNA catabolic process, exonucleolytic Source:UniProtKB1 Publication
Biological Process hippocampus development Source:Ensembl
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process neuron differentiation Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process Source:GO_Central1 Publication
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process RNA catabolic process Source:ProtInc1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process RNA processing Source:ProtInc1 Publication
Biological Process rRNA processing Source:Reactome
Biological Process spermatogenesis Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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