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XRN2

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Full Name

5'-3' Exoribonuclease 2

Function

Possesses 5'->3' exoribonuclease activity (By similarity).
May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).

Biological Process

Biological Process DNA catabolic process, exonucleolytic Source:UniProtKB1 Publication
Biological Process hippocampus development Source:Ensembl
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process neuron differentiation Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process Source:GO_Central1 Publication
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process RNA catabolic process Source:ProtInc1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process RNA processing Source:ProtInc1 Publication
Biological Process rRNA processing Source:Reactome
Biological Process spermatogenesis Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus

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Anti-XRN2 antibodies

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Mouse Anti-XRN2 Recombinant Antibody (7C5B10) (CBMAB-X0252-YC)

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Target: XRN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7C5B10

Application*: E, WB, P

Mouse Anti-XRN2 Recombinant Antibody (9F7G11) (CBMAB-X0251-YC)

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Target: XRN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9F7G11

Application*: E, WB, P

Rabbit Anti-XRN2 Recombinant Antibody (D6L5F) (CBMAB-X0250-YC)

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Target: XRN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D6L5F

Application*: WB, IP

Mouse Anti-XRN2 Recombinant Antibody (CBT3026) (V2LY-0625-LY495)

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Target: XRN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3026

Application*: WB, IH

Mouse Anti-XRN2 Recombinant Antibody (CBT2130) (V2LY-0625-LY494)

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Target: XRN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2130

Application*: WB, IH

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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