XRN2

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

5'-3' Exoribonuclease 2

Possesses 5'->3' exoribonuclease activity (By similarity).
May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).

Biological Process DNA catabolic process, exonucleolytic Source:UniProtKB1 Publication
Biological Process hippocampus development Source:Ensembl
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process neuron differentiation Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process Source:GO_Central1 Publication
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process RNA catabolic process Source:ProtInc1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process RNA processing Source:ProtInc1 Publication
Biological Process rRNA processing Source:Reactome
Biological Process spermatogenesis Source:UniProtKB1 Publication

Nucleus, nucleolus