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Mouse Anti-YWHAG Recombinant Antibody (16C3) (CBMAB-1216-LY)

This product is antibody recognizes YWHAG. The antibody 16C3 immunoassay techniques such as: ELISA, WB.
See all YWHAG antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
16C3
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Human 14-3-3 gamma 1-247 aa
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Introduction
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Entrez Gene ID
Human7532
Mouse22628
UniProt ID
HumanP61981
MouseP61982
Alternative Names
EIEE56; PPP1R170; 14-3-3GAMMA
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Biological Process
Biological Process cellular response to insulin stimulus Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:UniProtKB1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of neuron differentiation Source:UniProtKB1 Publication
Biological Process regulation of signal transduction Source:UniProtKB2 Publications
Biological Process regulation of synaptic plasticity Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Involvement in disease
Developmental and epileptic encephalopathy 56 (DEE56):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE56 is an autosomal dominant condition.
PTM
Phosphorylated by various PKC isozymes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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