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YWHAG

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq]

Full Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Biological Process

Biological Process cellular response to insulin stimulus Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:UniProtKB1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of neuron differentiation Source:UniProtKB1 Publication
Biological Process regulation of signal transduction Source:UniProtKB2 Publications
Biological Process regulation of synaptic plasticity Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication

Cellular Location

Cytoplasm

Involvement in disease

Developmental and epileptic encephalopathy 56 (DEE56):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE56 is an autosomal dominant condition.

PTM

Phosphorylated by various PKC isozymes.

Anti-YWHAG antibodies

Mouse Anti-YWHAG Recombinant Antibody (1B4) (CBMAB-A9984-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 1B4

Application*: SE, E

Mouse Anti-YWHAG Recombinant Antibody (3G3) (CBMAB-A9985-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: 3G3

Application*: WB, E

Mouse Anti-YWHAG Recombinant Antibody (CBYJT-5592) (CBMAB-T5225-YJ)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-5592

Application*: E, WB

Mouse Anti-YWHAG Recombinant Antibody (CBYJT-5593) (CBMAB-T5226-YJ)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-5593

Application*: IF, E, WB

Mouse Anti-YWHAG Recombinant Antibody (15B1) (CBMAB-1215-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 15B1

Application*: E, WB

Mouse Anti-YWHAG Recombinant Antibody (16C3) (CBMAB-1216-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 16C3

Application*: E, WB

Mouse Anti-YWHAG Recombinant Antibody (2T1) (CBMAB-1217-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 2T1

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (3F8) (CBMAB-1218-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F8

Application*: IP, WB

Mouse Anti-YWHAG Recombinant Antibody (505810) (CBMAB-1219-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 505810

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (63A1) (CBMAB-1220-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 63A1

Application*: WB, IH

Mouse Anti-YWHAG Recombinant Antibody (6A10) (CBMAB-1221-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: 6A10

Application*: E, WB

Mouse Anti-YWHAG Recombinant Antibody (9A70) (CBMAB-1222-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 9A70

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (9A71) (CBMAB-1223-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9A71

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (9i237) (CBMAB-1224-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Cattle, Chicken, Mouse, Rat

Clone: 9i237

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (AT4B9) (CBMAB-1225-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: AT4B9

Application*: E, WB

Mouse Anti-YWHAG Recombinant Antibody (CG31-2B6) (CBMAB-1227-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CG31-2B6

Application*: WB

Mouse Anti-YWHAG Recombinant Antibody (HS23) (CBMAB-1228-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Cattle, Chicken, Mouse, Rat, Zebrafish

Clone: HS23

Application*: WB, IC, IF

Mouse Anti-YWHAG Recombinant Antibody (J3H10) (CBMAB-1229-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: J3H10

Application*: WB, E, P

Mouse Anti-YWHAG Recombinant Antibody (KC21) (CBMAB-1230-LY)

SDS

Target: YWHAG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: KC21

Application*: WB, IC, IF

Rabbit Anti-YWHAG Recombinant Antibody (EPR9654(B)) (CBMAB-1861-CN)

SDS

Target: YWHAG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR9654(B)

Application*: WB

Rabbit Anti-YWHAG Recombinant Antibody (EPR9655(B)) (CBMAB-1862-CN)

SDS

Target: YWHAG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR9655(B)

Application*: F, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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