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Mouse Anti-ZFAND2B Recombinant Antibody (3A5) (CBMAB-Z0171-WJ)

This product is a mouse antibody that recognizes ZFAND2B. The antibody 3A5 can be used for immunoassay techniques such as: FC, WB.
See all ZFAND2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A5
Antibody Isotype
IgG2a
Application
FC, WB

Basic Information

Immunogen
ZFAND2B antibody was raised in mouse using a full length recombinant protein of human ZFAND2B produced in HEK293T cells.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
Zinc Finger AN1-Type Containing 2B
Introduction
ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. An important paralog of this gene is ZFAND2A.
Entrez Gene ID
130617
UniProt ID
Q8WV99
Alternative Names
AIRAPL
Function
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein targeting to ER Source:UniProtKB1 Publication
Biological Process regulation of insulin-like growth factor receptor signaling pathway Source:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:MGI1 Publication
Cellular Location
Endoplasmic reticulum membrane
PTM
Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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