Mouse Anti-ZFAND2B Recombinant Antibody (3D6) (CBMAB-Z0179-WJ)

Name: Mouse Anti-ZFAND2B Recombinant Antibody (3D6)
SKU: CBMAB-Z0179-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3D6

Application

FC, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.68 mg/mL

More Infomation

Target

Full Name

Zinc Finger AN1-Type Containing 2B

Introduction

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. An important paralog of this gene is ZFAND2A.

Entrez Gene ID

130617

UniProt ID

Q8WV99

Alternative Names

AIRAPL

Function

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Biological Process

Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein targeting to ER Source:UniProtKB1 Publication
Biological Process regulation of insulin-like growth factor receptor signaling pathway Source:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:MGI1 Publication

Cellular Location

Endoplasmic reticulum membrane

PTM

Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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