ZFAND2B

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. An important paralog of this gene is ZFAND2A.
Full Name
Zinc Finger AN1-Type Containing 2B
Function
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein targeting to ER Source:UniProtKB1 Publication
Biological Process regulation of insulin-like growth factor receptor signaling pathway Source:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:MGI1 Publication
Cellular Location
Endoplasmic reticulum membrane
PTM
Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.
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Anti-ZFAND2B antibodies

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Mouse Anti-ZFAND2B Recombinant Antibody (3A2) (CBMAB-Z0181-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A2
Application*: IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (1G10) (CBMAB-Z0180-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G10
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (3D6) (CBMAB-Z0179-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D6
Application*: F, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (1D5) (CBMAB-Z0178-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D5
Application*: IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (3E3) (CBMAB-Z0177-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E3
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (2E4) (CBMAB-Z0175-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E4
Application*: IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (2E11) (CBMAB-Z0174-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E11
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (1G9) (CBMAB-Z0173-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G9
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (2G10) (CBMAB-Z0172-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G10
Application*: F, WB
Datasheet SDS

Mouse Anti-ZFAND2B Recombinant Antibody (3A5) (CBMAB-Z0171-WJ)

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Target: ZFAND2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3A5
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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