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ANXA5 Matched Antibody Pair (083) (APMAB-083LY)

This antibody pair set can be used for detecting and quantifying protein level of human ANXA5.
See all ANXA5 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ANXA5 polyclonal antibody, 100 ug
Detection Antibody
Anti-ANXA5 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
Alternative Names
Annexin A5; Placental Anticoagulant Protein 4; Placental Anticoagulant Protein I; Vascular Anticoagulant-Alpha; Thromboplastin Inhibitor; Calphobindin I; Anchorin CII; Endonexin II; Lipocortin V; Annexin V; Annexin-5;
Entrez Gene ID
308
UniProt ID
P08758

Haeckel, A., Ascher, L., Beindorff, N., Prasad, S., Garczyńska, K., Guo, J., & Schellenberger, E. (2021). Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications. Apoptosis, 1-14.

Dryllis, G., Giannopoulos, A., Zoi, C., Pouliakis, A., Logothetis, E., Voulgarelis, M., ... & Politou, M. (2020). Correlation of single nucleotide polymorphisms in the promoter region of the ANXA5 (annexin A5) gene with recurrent miscarriages in women of Greek origin. The Journal of Maternal-Fetal & Neonatal Medicine, 33(9), 1538-1543.

Bolean, M., Izzi, B., Bottini, M., Ramos, A. P., Millán, J. L., Hoylaerts, M. F., & Ciancaglini, P. (2020). Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 1864(8), 129629.

Terashima, R., Saigo, T., Laoharatchatathanin, T., Kurusu, S., Brachvogel, B., Pöschl, E., & Kawaminami, M. (2020). Augmentation of Nr4a3 and suppression of Fshb expression in the pituitary gland of female Annexin A5 null mouse. Journal of the Endocrine Society, 4(9), bvaa096.

Kang, T. H., Park, J. H., Yang, A., Park, H. J., Lee, S. E., Kim, Y. S., ... & Hung, C. F. (2020). Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment. Nature communications, 11(1), 1-16.

Yu, C., Muñoz, L. E., Mallavarapu, M., Herrmann, M., & Finnemann, S. C. (2019). Annexin A5 regulates surface αvβ5 integrin for retinal clearance phagocytosis. Journal of cell science, 132(20), jcs232439.

Danisik, H., Bogdanova, N., & Markoff, A. (2019). Micromolar zinc in Annexin A5 anticoagulation as a potential remedy for RPRGL3-associated recurrent pregnancy loss. Reproductive Sciences, 26(3), 348-356.

de Jong, R. C., Pluijmert, N. J., de Vries, M. R., Pettersson, K., Atsma, D. E., Jukema, J. W., & Quax, P. H. (2018). Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response. Scientific reports, 8(1), 1-10.

Zhang, B., Zeng, X., Xu, Y., Zhang, Y., Huang, N., Gu, Y., ... & Liu, X. (2017). The association between annexin A5 (ANXA5) gene polymorphism and left ventricular hypertrophy (LVH) in Chinese endogenous hypertension patients. Medicine, 96(44).

Baek, H. S., Park, N., Kwon, Y. J., Ye, D. J., Shin, S., & Chun, Y. J. (2017). Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ–nuclear factor-κB signaling pathway in prostate cancer cells. Oncotarget, 8(43), 74263.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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