ANXA5
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
Full Name
Annexin A5
Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Biological Process
Blood coagulation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of coagulation Source: InterPro
Platelet degranulation Source: Reactome
Signal transduction Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of coagulation Source: InterPro
Platelet degranulation Source: Reactome
Signal transduction Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Collagen-containing extracellular matrix; Cytoplasm; Focal adhesion; Membrane
Involvement in disease
Pregnancy loss, recurrent, 3 (RPRGL3): A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
PTM
S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
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Anti-ANXA5 antibodies
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CompareTarget: ANXA5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CF030
Application*: WB, IP, IC, E
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Bird
Clone: CBYC-A636
Application*: WB, IP
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: VAA-33
Application*: E, FC, WB
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: RUU-WAC2A
Application*: E, IC, IF, P
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3B9F3
Application*: WB, FC, E
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 3B9B7
Application*: WB, FC, E, IH
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F4-1A5
Application*: E, IF, P, IP, WB
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: H3
Application*: E, IC, IP, WB
Target: ANXA5
Expressed Host: E. coli
Sequence: Amino Acid: 1-320
Target: ANXA5
Expressed Host: E. coli
Sequence: Amino Acid: 1-320
Target: ANXA5
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3784
Application*: WB, IC, F
Target: ANXA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3603
Application*: WB, F
Target: ANXA5
Specificity: Human
Target: ANXA5
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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