Cattle ANXA5 ELISA Kit (V2LY-0626-LY685)

Name: Cattle ANXA5 ELISA Kit
SKU: V2LY-0626-LY685
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.022 ng/mL

Detection Range

0.05-30 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Cattle

Assay Type

Sandwich

Reactivity

Cattle

Assay Time

1.5 h

Molecule Mass

36.1 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Annexin A5

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Biological Process

Blood coagulation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of coagulation Source: InterPro
Platelet degranulation Source: Reactome
Signal transduction Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Extracellular region; Collagen-containing extracellular matrix; Cytoplasm; Focal adhesion; Membrane

Involvement in disease

Pregnancy loss, recurrent, 3 (RPRGL3): A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.

PTM

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.

Haeckel, A., Ascher, L., Beindorff, N., Prasad, S., Garczyńska, K., Guo, J., & Schellenberger, E. (2021). Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications. Apoptosis, 1-14.

Dryllis, G., Giannopoulos, A., Zoi, C., Pouliakis, A., Logothetis, E., Voulgarelis, M., ... & Politou, M. (2020). Correlation of single nucleotide polymorphisms in the promoter region of the ANXA5 (annexin A5) gene with recurrent miscarriages in women of Greek origin. The Journal of Maternal-Fetal & Neonatal Medicine, 33(9), 1538-1543.

Bolean, M., Izzi, B., Bottini, M., Ramos, A. P., Millán, J. L., Hoylaerts, M. F., & Ciancaglini, P. (2020). Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 1864(8), 129629.

Terashima, R., Saigo, T., Laoharatchatathanin, T., Kurusu, S., Brachvogel, B., Pöschl, E., & Kawaminami, M. (2020). Augmentation of Nr4a3 and suppression of Fshb expression in the pituitary gland of female Annexin A5 null mouse. Journal of the Endocrine Society, 4(9), bvaa096.

Kang, T. H., Park, J. H., Yang, A., Park, H. J., Lee, S. E., Kim, Y. S., ... & Hung, C. F. (2020). Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment. Nature communications, 11(1), 1-16.

Yu, C., Muñoz, L. E., Mallavarapu, M., Herrmann, M., & Finnemann, S. C. (2019). Annexin A5 regulates surface αvβ5 integrin for retinal clearance phagocytosis. Journal of cell science, 132(20), jcs232439.

Danisik, H., Bogdanova, N., & Markoff, A. (2019). Micromolar zinc in Annexin A5 anticoagulation as a potential remedy for RPRGL3-associated recurrent pregnancy loss. Reproductive Sciences, 26(3), 348-356.

de Jong, R. C., Pluijmert, N. J., de Vries, M. R., Pettersson, K., Atsma, D. E., Jukema, J. W., & Quax, P. H. (2018). Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response. Scientific reports, 8(1), 1-10.

Zhang, B., Zeng, X., Xu, Y., Zhang, Y., Huang, N., Gu, Y., ... & Liu, X. (2017). The association between annexin A5 (ANXA5) gene polymorphism and left ventricular hypertrophy (LVH) in Chinese endogenous hypertension patients. Medicine, 96(44).

Baek, H. S., Park, N., Kwon, Y. J., Ye, D. J., Shin, S., & Chun, Y. J. (2017). Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ–nuclear factor-κB signaling pathway in prostate cancer cells. Oncotarget, 8(43), 74263.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human ANXA5 ELISA Kit (CAT#: V2LY-0626-LY1389)

Human ANXA5 ELISA Kit (2) (CAT#: V2LY-0626-LY3578)

Rat Anxa5 ELISA Kit (CAT#: V2LY-0626-LY895)

ANXA5 Matched Antibody Pair (082) (CAT#: APMAB-082LY)

ANXA5 Matched Antibody Pair (083) (CAT#: APMAB-083LY)

Human Recombinant ANXA5 protein, His Tag (CAT#: V2LY-0526-LY2124)

Human Recombinant ANXA5 protein, Biotin Conjugated (CAT#: V2LY-0526-LY2125)

Human Recombinant ANXA5 protein (CAT#: V2LY-0526-LY2126)

Antibody Pairs

ANXA5 Matched Antibody Pair (082) (CAT#: APMAB-082LY)

ANXA5 Matched Antibody Pair (083) (CAT#: APMAB-083LY)

Related Products

Human ANXA5 ELISA Kit (CAT#: V2LY-0626-LY1389)

Human Recombinant ANXA5 protein (CAT#: V2LY-0526-LY2126)

Human Recombinant ANXA5 protein, His Tag (CAT#: V2LY-0526-LY2124)

ANXA5 Matched Antibody Pair (083) (CAT#: APMAB-083LY)

Mouse Anti-ANXA5 Recombinant Antibody (CBT3784) (CAT#: V2LY-0625-LY309)

Mouse Anti-ANXA5 Recombinant Antibody (3B9F3) (CAT#: CBMAB-A2928-YC)

Rat Anxa5 ELISA Kit (CAT#: V2LY-0626-LY895)

Mouse Anti-ANXA5 Recombinant Antibody (CBYC-A636) (CAT#: CBMAB-A2934-YC)

Human Recombinant ANXA5 protein, Biotin Conjugated (CAT#: V2LY-0526-LY2125)

ANXA5 Matched Antibody Pair (082) (CAT#: APMAB-082LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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