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ATF6 Matched Antibody Pair (115) (APMAB-115LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ATF6 polyclonal antibody, 100 ug
Detection Antibody
Anti-ATF6 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Alternative Names
Activating Transcription Factor 6; CAMP-Dependent Transcription Factor ATF-6 Alpha; Activating Transcription Factor 6 Alpha; Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha; ATF6-Alpha; ACHM7; ATF6A;
Entrez Gene ID
22926
UniProt ID
P18850
More Infomation

Shen, Y., Li, R., Yu, S., Zhao, Q., Wang, Z., Sheng, H., & Yang, W. (2021). Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. Journal of the American Heart Association, e020216.

Ji, Z., Zhou, Z. L., Hao, Q., Zhao, L., Cui, C., Huang, S. B., ... & Shen, Y. Q. (2021). Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish. Journal of Molecular Neuroscience, 71(4), 734-745.

Cheng, N., Shi, J. H., Jin, Y., Shi, Y. B., Liu, X. D., Zhang, H. P., ... & Zhang, S. J. (2021). Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Frontiers in Surgery, 8, 212.

Tao, J., Chen, H., Li, X., & Wang, J. (2021). The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis. Journal of Orthopaedic Surgery and Research, 16(1), 1-8.

Stengel, S. T., Fazio, A., Lipinski, S., Jahn, M. T., Aden, K., Ito, G., ... & Rosenstiel, P. (2020). Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress. Gastroenterology, 159(4), 1357-1374.

Liu, F., Chang, L., & Hu, J. (2020). Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer. Journal of reproductive immunology, 139, 103120.

Du, Y., Liu, X., Zhu, X., Liu, Y., Wang, X., & Wu, X. (2020). Activating transcription factor 6 reduces Aβ1–42 and restores memory in Alzheimer’s disease model mice. International Journal of Neuroscience, 130(10), 1015-1023.

Shen, T., Li, Y., Chen, Z., Liang, S., Qiu, Y., Zhu, L., ... & Qiu, L. (2020). Activating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C/EBPβ to the upstream-promoter during ER stress. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1863(2), 194488.

Liu, S., Wang, W., Ge, W., Lv, X., Han, Z., Li, Y., ... & Song, L. (2020). An activating transcription factor 6 beta (ATF6β) regulates apoptosis of hemocyte during immune response in Crassostrea gigas. Fish & shellfish immunology, 99, 442-451.

Jegal, K. H., Park, S. M., Cho, S. S., Byun, S. H., Ku, S. K., Kim, S. C., ... & Cho, I. J. (2017). Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1864(7), 1295-1307.

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For research use only. Not intended for any clinical use.

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