Cattle FAS ELISA Kit (V2LY-0626-LY2656)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.58 ng/mL
Detection Range
1-400 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Cattle
Assay Type
Sandwich
Reactivity
Cattle
Assay Time
1.5 h
Molecule Mass
36.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Fas Cell Surface Death Receptor
Alternative Names
Fas Cell Surface Death Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Fas (TNF Receptor Superfamily, Member 6); Apoptosis-Mediating Surface Antigen FAS; TNF Receptor Superfamily Member 6; FASLG Receptor; CD95 Antigen; TNFRSF6; APT1; FAS1; Mutant Tumor Necrosis Receptor Superfamily Member 6;
Research Area
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Biological Process
Activation-induced cell death of T cells Source: GO_Central
Apoptotic process Source: MGI
Cellular response to amino acid starvation Source: CAFA
Cellular response to hyperoxia Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Fas signaling pathway Source: CAFA
Immune response Source: InterPro
Motor neuron apoptotic process Source: GO_Central
Necroptotic signaling pathway Source: BHF-UCL
Negative regulation of apoptotic process Source: GO_Central
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: CAFA
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: CAFA
Positive regulation of protein phosphorylation Source: CAFA
Protein-containing complex assembly Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of stress-activated MAPK cascade Source: CAFA
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Cell membrane; Membrane raft
Isoform 2&3&4&5&6: Secreted
Involvement in disease
Autoimmune lymphoproliferative syndrome 1A (ALPS1A):
A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Topology
Extracellular: 26-173
Helical: 174-190
Cytoplasmic: 191-335
PTM
(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068).
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CD95 protein (CAT#: V2LY-0526-LY1509)

Cynomolgus Recombinant CD95 protein, hFc Tag (CAT#: V2LY-0526-LY1510)

Mouse Recombinant FAS protein, His Tag (CAT#: V2LY-0526-LY8299)

Rat Recombinant FAS protein, hFc Tag (CAT#: V2LY-0526-LY9374)

Rat Recombinant FAS protein, His Tag (CAT#: V2LY-0526-LY9375)

FAS Matched Antibody Pair (410) (CAT#: APMAB-410LY)

Antibody Pairs

FAS Matched Antibody Pair (410) (CAT#: APMAB-410LY)

Related Products

Rabbit Anti-FAS Recombinant Antibody (EG1181) (CAT#: CBMAB-EN1420-LY)

Mouse Anti-FAS Recombinant Antibody (CBXF-2490) (CAT#: CBMAB-F3561-CQ)

Rat Anti-FAS Recombinant Antibody (CBXF-2369) (CAT#: V2LY-0925-LY47)

Mouse Anti-FAS Recombinant Antibody (CBT2359) (CAT#: V2LY-0625-LY2700)

Mouse Anti-FAS Recombinant Antibody (EC147) (CAT#: V2LY-0624-LY147)

Human Anti-FAS Recombinant Antibody (CBXC-0925) (CAT#: CBMAB-C2040-CQ)

FAS Matched Antibody Pair (410) (CAT#: APMAB-410LY)

Mouse Anti-FAS Recombinant Antibody (CBXF-2570) (CAT#: CBMAB-F0807-CQ)

Cynomolgus Recombinant CD95 protein (CAT#: V2LY-0526-LY1509)

Mouse Anti-FAS Recombinant Antibody (CBT2693) (CAT#: V2LY-0625-LY2702)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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