Cattle MX1 ELISA Kit (V2LY-0626-LY793)

Name: Cattle MX1 ELISA Kit
SKU: V2LY-0626-LY793
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0092 ng/mL

Detection Range

0.02-3.8 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Cattle

Assay Type

Sandwich

Reactivity

Cattle

Assay Time

1.5 h

Molecule Mass

74.8 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

MX Dynamin Like GTPase 1

Function

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Biological Process

Antiviral innate immune response Source: ARUK-UCL
Apoptotic process Source: ProtInc
Defense response Source: ProtInc
Defense response to virus Source: UniProtKB
Innate immune response Source: UniProtKB
Interleukin-27-mediated signaling pathway Source: ARUK-UCL
Negative regulation of viral genome replication Source: UniProtKB
Response to type I interferon Source: UniProtKB
Response to virus Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
perinuclear region
Note: Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845).
Isoform 2:
Nucleus
Cytoplasm
Note: Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636).

PTM

ISGylated.

McKellar, J., Arnaud-Arnould, M., Chaloin, L., Tauziet, M., Arpin-André, C., Pourcelot, O., ... & Goujon, C. (2023). An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses. Journal of Biological Chemistry, 299(1).

Bayrou, C., Van Laere, A. S., Dam Van, P., Moula, N., Garigliany, M. M., & Desmecht, D. (2023). Anti-Schmallenberg virus activities of type I/III interferons-induced Mx1 GTPases from different mammalian species. Viruses, 15(5), 1055.

McKellar, J., Arnaud-Arnould, M., Chaloin, L., Tauziet, M., Arpin-André, C., Pourcelot, O., ... & Goujon, C. (2022). The N-terminal domain of MX1 proteins is essential for their antiviral activity against different families of RNA viruses. bioRxiv, 2022-05.

Selvaramesh, A. S., Kumar, P., Mishra, C., Bhattacharya, T. K., Bhushan, B., Tiwari, A. K., ... & Sharma, A. (2020). Cloning, characterization and expression of GTPase effecter domain of chicken Mx1 gene. The Indian Journal of Animal Sciences, 90(12), 1602-1605.

Sehgal, P. B., Yuan, H., Scott, M. F., Deng, Y., Liang, F. X., & Mackiewicz, A. (2020). Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV. Journal of Biological Chemistry, 295(52), 18023-18035.

Dam Van, P., Desmecht, D., Garigliany, M. M., Bui Tran Anh, D., & Van Laere, A. S. (2019). Anti-influenza a virus activities of type I/III interferons-induced Mx1 GTPases from different mammalian species. Journal of Interferon & Cytokine Research, 39(5), 274-282.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human MX1 ELISA Kit (CAT#: V2LY-0626-LY4746)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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