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Mouse Anti-MX1 Recombinant Antibody (CBFYM-2849) (CBMAB-M3042-FY)

This product is mouse antibody that recognizes MX1. The antibody CBFYM-2849 can be used for immunoassay techniques such as: ICC, IHC-Fr, IHC-P, ELISA, WB.
See all MX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2849
Antibody Isotype
IgG
Application
ICC, IHC-Fr, IHC-P, ELISA, WB

Basic Information

Immunogen
The antibody is a mouse monoclonal antibody raised against MX1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MX Dynamin Like GTPase 1
Introduction
This gene encodes a guanosine triphosphate -metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4599
UniProt ID
P20591
Alternative Names
MX Dynamin Like GTPase 1; Interferon-Regulated Resistance GTP-Binding Protein MxA; Interferon-Inducible Protein P78; Interferon-Induced Protein P78; Myxoma Resistance Protein 1; IFI-78K; Myxovirus (Influenza) Resistance 1, Homolog Of Murine (Interferon-Inducible Protein P78); Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 (Mouse)
Function
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
Biological Process
Antiviral innate immune response Source: ARUK-UCL
Apoptotic process Source: ProtInc
Defense response Source: ProtInc
Defense response to virus Source: UniProtKB
Innate immune response Source: UniProtKB
Interleukin-27-mediated signaling pathway Source: ARUK-UCL
Negative regulation of viral genome replication Source: UniProtKB
Response to type I interferon Source: UniProtKB
Response to virus Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
perinuclear region
Note: Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845).
Isoform 2:
Nucleus
Cytoplasm
Note: Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636).
PTM
ISGylated.

McKellar, J., Arnaud-Arnould, M., Chaloin, L., Tauziet, M., Arpin-André, C., Pourcelot, O., ... & Goujon, C. (2023). An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses. Journal of Biological Chemistry, 299(1).

Bayrou, C., Van Laere, A. S., Dam Van, P., Moula, N., Garigliany, M. M., & Desmecht, D. (2023). Anti-Schmallenberg virus activities of type I/III interferons-induced Mx1 GTPases from different mammalian species. Viruses, 15(5), 1055.

McKellar, J., Arnaud-Arnould, M., Chaloin, L., Tauziet, M., Arpin-André, C., Pourcelot, O., ... & Goujon, C. (2022). The N-terminal domain of MX1 proteins is essential for their antiviral activity against different families of RNA viruses. bioRxiv, 2022-05.

Selvaramesh, A. S., Kumar, P., Mishra, C., Bhattacharya, T. K., Bhushan, B., Tiwari, A. K., ... & Sharma, A. (2020). Cloning, characterization and expression of GTPase effecter domain of chicken Mx1 gene. The Indian Journal of Animal Sciences, 90(12), 1602-1605.

Sehgal, P. B., Yuan, H., Scott, M. F., Deng, Y., Liang, F. X., & Mackiewicz, A. (2020). Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV. Journal of Biological Chemistry, 295(52), 18023-18035.

Dam Van, P., Desmecht, D., Garigliany, M. M., Bui Tran Anh, D., & Van Laere, A. S. (2019). Anti-influenza a virus activities of type I/III interferons-induced Mx1 GTPases from different mammalian species. Journal of Interferon & Cytokine Research, 39(5), 274-282.

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For research use only. Not intended for any clinical use.

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