CD80 Matched Antibody Pair (236) (APMAB-236LY)

Name: CD80 Matched Antibody Pair (236)
SKU: APMAB-236LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-CD80 monoclonal, IgG2b antibody, 100 ug

Detection Antibody

Anti-CD80 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

Alternative Names

CD80 Molecule; CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen); B-Lymphocyte Activation Antigen B7; CTLA-4 Counter-Receptor B7.1; Activation B7-1 Antigen; CD28LG1; CD28LG; LAB7; BB1;

Entrez Gene ID

941

UniProt ID

P33681

More Infomation

Tekguc, M., Wing, J. B., Osaki, M., Long, J., & Sakaguchi, S. (2021). Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells. Proceedings of the National Academy of Sciences, 118(30).

Zhao, Y., Lee, C. K., Lin, C. H., Gassen, R. B., Xu, X., Huang, Z., ... & Hui, E. (2019). PD-L1: CD80 cis-heterodimer triggers the co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 pathways. Immunity, 51(6), 1059-1073.

Haabeth, O. A. W., Blake, T. R., McKinlay, C. J., Tveita, A. A., Sallets, A., Waymouth, R. M., ... & Levy, R. (2019). Local delivery of Ox40l, Cd80, and Cd86 mRNA kindles global anticancer immunity. Cancer research, 79(7), 1624-1634.

Jiménez-Uribe, A. P., Valencia-Martínez, H., Carballo-Uicab, G., Vallejo-Castillo, L., Medina-Rivero, E., Chacón-Salinas, R., ... & Pérez-Tapia, S. M. (2019). CD80 expression correlates with IL-6 production in THP-1-like macrophages costimulated with LPS and dialyzable leukocyte extract (Transferon®). Journal of immunology research, 2019.

Kleinpeter, P., Remy-Ziller, C., Winter, E., Gantzer, M., Nourtier, V., Kempf, J., ... & Marchand, J. B. (2019). By binding CD80 and CD86, the vaccinia virus M2 protein blocks their interactions with both CD28 and CTLA4 and potentiates CD80 binding to PD-L1. Journal of virology, 93(11), e00207-19.

Li, W., Kim, T. I., Kim, J. H., & Chung, H. S. (2019). Immune checkpoint PD-1/PD-L1 CTLA-4/CD80 are blocked by Rhus verniciflua Stokes and its active compounds. Molecules, 24(22), 4062.

Huang, Y., Wang, Z., Zheng, Q., Tang, J., Cai, J., Lu, Y., & Jian, J. (2018). Conservation of structural and interactional features of CD28 and CD80/86 molecules from Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 72, 95-103.

Siokis, A., Robert, P. A., Demetriou, P., Dustin, M. L., & Meyer-Hermann, M. (2018). F-actin-driven CD28-CD80 localization in the immune synapse. Cell reports, 24(5), 1151-1162.

Bengsch, F., Knoblock, D. M., Liu, A., McAllister, F., & Beatty, G. L. (2017). CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. Cancer Immunology, Immunotherapy, 66(12), 1609-1617.

Mo, Z. Q., Wang, J. L., Yang, M., Ni, L. Y., Wang, H. Q., Lao, G. F., ... & Dan, X. M. (2017). Characterization and expression analysis of grouper (Epinephelus coioides) co-stimulatory molecules CD83 and CD80/86 post Cryptocaryon irritans infection. Fish & shellfish immunology, 67, 467-474.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD80 protein, hFc Tag (CAT#: V2LY-0526-LY1677)

Cynomolgus, Rhesus Recombinant CD80 protein, His Tag (CAT#: V2LY-0526-LY1678)

Human Recombinant CD80 protein (CAT#: V2LY-0526-LY2238)

Human Recombinant CD80 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2239)

Human Recombinant CD80 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2240)

Human Recombinant CD80 protein, ECD, His Tag (CAT#: V2LY-0526-LY2241)

Human Recombinant CD80 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2242)

Mouse Recombinant CD80 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY7836)

Mouse Recombinant CD80 protein, hFc Tag (CAT#: V2LY-0526-LY7837)

Mouse Recombinant CD80 protein, His Tag (CAT#: V2LY-0526-LY7838)

Related Products

Rat Recombinant CD80 protein, His Tag (CAT#: V2LY-0526-LY9168)

Mouse Recombinant CD80 protein, hFc Tag (CAT#: V2LY-0526-LY7837)

Rat Recombinant CD80 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY9167)

Human Recombinant CD80 protein, ECD, His Tag (CAT#: V2LY-0526-LY2241)

Cynomolgus, Rhesus Recombinant CD80 protein, His Tag (CAT#: V2LY-0526-LY1678)

Human Recombinant CD80 protein (CAT#: V2LY-0526-LY2238)

Rabbit Anti-CD80 Recombinant Antibody (18) (CAT#: CBMAB-C3437-LY)

Mouse Anti-CD80 Recombinant Antibody (CBYY-0978) (CAT#: CBMAB-0981-YY)

Mouse Anti-CD80 Recombinant Antibody (3E10) (CAT#: CBMAB-C5923-LY)

Rabbit Anti-CD80 Recombinant Antibody (
3C3) (CAT#: V2LY-0725-LY1106)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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