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CDA Matched Antibody Pair (242) (APMAB-242LY)

This antibody pair set can be used for detecting and quantifying protein level of human CDA.
See all CDA antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CDA polyclonal antibody, 100 ug
Detection Antibody
Anti-CDA Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia. Among its related pathways are Pyrimidine metabolism (KEGG) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity.
Alternative Names
Cytidine Deaminase; Cytidine Aminohydrolase; CDD; Cytosine Nucleoside Deaminase; Small Cytidine Deaminase; EC 3.5.4.5;
Entrez Gene ID
UniProt ID

Frances, A., & Cordelier, P. (2020). The emerging role of cytidine deaminase in human diseases: a new opportunity for therapy?. Molecular Therapy, 28(2), 357-366.

Bjånes, T. K., Jordheim, L. P., Schjøtt, J., Kamceva, T., Cros-Perrial, E., Langer, A., ... & Riedel, B. (2020). Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. Drug Metabolism and Disposition, 48(3), 153-158.

Murakami, Y., Kimura, Y., Kawahara, A., Mitsuyasu, S., Miyake, H., Tohyama, K., ... & Kuwano, M. (2019). The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes. Oncotarget, 10(23), 2270.

Liu, W., Shang, F., Chen, Y., Lan, J., Wang, L., Chen, J., ... & Xu, Y. (2019). Biochemical and structural analysis of the Klebsiella pneumoniae cytidine deaminase CDA. Biochemical and biophysical research communications, 519(2), 280-286.

Moro-Bulnes, A., Castillo-Acosta, V. M., Valente, M., Carrero-Lérida, J., Pérez-Moreno, G., Ruiz-Pérez, L. M., & González-Pacanowska, D. (2019). Contribution of cytidine deaminase to thymidylate biosynthesis in trypanosoma brucei: intracellular localization and properties of the enzyme. Msphere, 4(4), e00374-19.

Peters, G. J., Giovannetti, E., Honeywell, R. J., & Ciccolini, J. (2019). Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?. British journal of clinical pharmacology, 85(6), 1213.

Cohen, R., Preta, L. H., Joste, V., Curis, E., Huillard, O., Jouinot, A., ... & Blanchet, B. (2019). Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours. British journal of clinical pharmacology, 85(6), 1227-1238.

Fanciullino, R., Farnault, L., Donnette, M., Imbs, D. C., Roche, C., Venton, G., ... & Costello, R. (2018). CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine. Blood Advances, 2(5), 462-469.

Rajabpour, A., Afgar, A., Mahmoodzadeh, H., Radfar, J. E. D., Rajaei, F., & Teimoori-Toolabi, L. (2017). MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells. Cancer chemotherapy and pharmacology, 80(4), 765-775.

Corrie, P., Qian, W., Gopinathan, A., Williams, M., Brais, R., Valle, J. W., ... & Jodrell, D. (2017). Strong tumour cytidine deaminase (CDA) staining predicts for improved survival associated with sequential nab-Paclitaxel (nabP) and gemcitabine (GEM) chemotherapy as first line treatment of patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC). Annals of Oncology, 28, v251-v252.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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