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CEACAM1 Matched Antibody Pair (251) (APMAB-251LY)

This antibody pair set can be used for detecting and quantifying protein level of human CEACAM1.
See all CEACAM1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-CEACAM1 monoclonal antibody, 100 ug
Detection Antibody
Anti-CEACAM1 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein); CD66a Antigen; BGP1; BGP; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1;
Entrez Gene ID
634
UniProt ID
P13688

Hayashi, S., Osada, Y., Miura, K., & Simizu, S. (2020). Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Biochemistry and biophysics reports, 21, 100734.

Weng, C. Y., Hu, X. Y., & Wang, Y. J. (2020). Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. 3 Biotech, 10(3), 1-19.

Kleefeldt, F., Bömmel, H., Broede, B., Thomsen, M., Pfeiffer, V., Wörsdörfer, P., ... & Ergün, S. (2019). Aging‐related carcinoembryonic antigen‐related cell adhesion molecule 1 signaling promotes vascular dysfunction. Aging cell, 18(6), e13025.

Wang, N., Wang, Q., Chi, J., Xiang, F., Lin, M., Wang, W., ... & Feng, Y. (2019). Carcinoembryonic antigen cell adhesion molecule 1 inhibits the antitumor effect of neutrophils in tongue squamous cell carcinoma. Cancer science, 110(2), 519-529.

Calinescu, A., Turcu, G., Nedelcu, R. I., Brinzea, A., Hodorogea, A., Antohe, M., ... & Badarau, I. A. (2018). On the dual role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human malignancies. Journal of immunology research, 2018.

Horst, A. K., Wegscheid, C., Schaefers, C., Schiller, B., Neumann, K., Lunemann, S., ... & Tiegs, G. (2018). Carcinoembryonic antigen‐related cell adhesion molecule 1 controls IL‐2‐dependent regulatory T‐cell induction in immune‐mediated hepatitis in mice. Hepatology, 68(1), 200-214.

Ghadieh, H. E., Muturi, H. T., Russo, L., Marino, C. C., Ghanem, S. S., Khuder, S. S., ... & Najjar, S. M. (2018). Exenatide induces carcinoembryonic antigen‐related cell adhesion molecule 1 expression to prevent hepatic steatosis. Hepatology communications, 2(1), 35-47.

Li, J., Liu, X., Duan, Y., Wang, H., Su, W., Wang, Y., ... & Fan, Y. (2018). Abnormal expression of circulating and tumor-infiltrating carcinoembryonic antigen-related cell adhesion molecule 1 in patients with glioma. Oncology letters, 15(3), 3496-3503.

Xi, R., Pun, I. H. Y., Menezes, S. V., Fouani, L., Kalinowski, D. S., Huang, M. L., ... & Kovacevic, Z. (2017). Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen–Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1). Molecular pharmacology, 91(5), 499-517.

Heinrich, G., Muturi, H. T., Rezaei, K., Al-Share, Q. Y., DeAngelis, A. M., Bowman, T. A., ... & Najjar, S. M. (2017). Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity. Frontiers in endocrinology, 8, 54.

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For research use only. Not intended for any clinical use.

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