CEACAM1 Matched Antibody Pair (252) (APMAB-252LY)

Name: CEACAM1 Matched Antibody Pair (252)
SKU: APMAB-252LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-CEACAM1 monoclonal antibody, 100 ug

Detection Antibody

Anti-CEACAM1 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

Alternative Names

Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein); CD66a Antigen; BGP1; BGP; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1;

Entrez Gene ID

634

UniProt ID

P13688

More Infomation

Hayashi, S., Osada, Y., Miura, K., & Simizu, S. (2020). Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Biochemistry and biophysics reports, 21, 100734.

Weng, C. Y., Hu, X. Y., & Wang, Y. J. (2020). Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. 3 Biotech, 10(3), 1-19.

Kleefeldt, F., Bömmel, H., Broede, B., Thomsen, M., Pfeiffer, V., Wörsdörfer, P., ... & Ergün, S. (2019). Aging‐related carcinoembryonic antigen‐related cell adhesion molecule 1 signaling promotes vascular dysfunction. Aging cell, 18(6), e13025.

Wang, N., Wang, Q., Chi, J., Xiang, F., Lin, M., Wang, W., ... & Feng, Y. (2019). Carcinoembryonic antigen cell adhesion molecule 1 inhibits the antitumor effect of neutrophils in tongue squamous cell carcinoma. Cancer science, 110(2), 519-529.

Calinescu, A., Turcu, G., Nedelcu, R. I., Brinzea, A., Hodorogea, A., Antohe, M., ... & Badarau, I. A. (2018). On the dual role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human malignancies. Journal of immunology research, 2018.

Horst, A. K., Wegscheid, C., Schaefers, C., Schiller, B., Neumann, K., Lunemann, S., ... & Tiegs, G. (2018). Carcinoembryonic antigen‐related cell adhesion molecule 1 controls IL‐2‐dependent regulatory T‐cell induction in immune‐mediated hepatitis in mice. Hepatology, 68(1), 200-214.

Ghadieh, H. E., Muturi, H. T., Russo, L., Marino, C. C., Ghanem, S. S., Khuder, S. S., ... & Najjar, S. M. (2018). Exenatide induces carcinoembryonic antigen‐related cell adhesion molecule 1 expression to prevent hepatic steatosis. Hepatology communications, 2(1), 35-47.

Li, J., Liu, X., Duan, Y., Wang, H., Su, W., Wang, Y., ... & Fan, Y. (2018). Abnormal expression of circulating and tumor-infiltrating carcinoembryonic antigen-related cell adhesion molecule 1 in patients with glioma. Oncology letters, 15(3), 3496-3503.

Xi, R., Pun, I. H. Y., Menezes, S. V., Fouani, L., Kalinowski, D. S., Huang, M. L., ... & Kovacevic, Z. (2017). Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen–Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1). Molecular pharmacology, 91(5), 499-517.

Heinrich, G., Muturi, H. T., Rezaei, K., Al-Share, Q. Y., DeAngelis, A. M., Bowman, T. A., ... & Najjar, S. M. (2017). Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity. Frontiers in endocrinology, 8, 54.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CEACAM1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY3077)

Human Recombinant CEACAM1 protein, ECD, His Tag (CAT#: V2LY-0526-LY3078)

Mouse Recombinant CEACAM1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8094)

Mouse Recombinant CEACAM1 protein, His Tag (CAT#: V2LY-0526-LY8095)

Rat Recombinant CEACAM1 protein, His Tag (CAT#: V2LY-0526-LY9280)

CEACAM1 Matched Antibody Pair (251) (CAT#: APMAB-251LY)

CEACAM1 Matched Antibody Pair (253) (CAT#: APMAB-253LY)

Antibody Pairs

CEACAM1 Matched Antibody Pair (251) (CAT#: APMAB-251LY)

CEACAM1 Matched Antibody Pair (253) (CAT#: APMAB-253LY)

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Human Recombinant CEACAM1 protein, ECD, His Tag (CAT#: V2LY-0526-LY3078)

Isotype control

For research use only. Not intended for any clinical use.

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