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CEACAM1

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 1
Function
Isoform 1:
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).
Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763).
Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226).
Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730).
Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763).
Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226).
Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity).
Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity).
Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity).
Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity).
Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).
Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity).
Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724).
Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity).
Negatively regulates osteoclastogenesis (By similarity).
Isoform 8:
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).
Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity).
Biological Process
Angiogenesis Source: UniProtKB
Bile acid and bile salt transport Source: UniProtKB
Blood vessel development Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Cell migration Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Common myeloid progenitor cell proliferation Source: UniProtKB
Granulocyte colony-stimulating factor signaling pathway Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Insulin catabolic process Source: UniProtKB
Insulin receptor internalization Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of cytotoxic T cell degranulation Source: UniProtKB
Negative regulation of fatty acid biosynthetic process Source: UniProtKB
Negative regulation of granulocyte differentiation Source: UniProtKB
Negative regulation of hepatocyte proliferation Source: UniProtKB
Negative regulation of interleukin-1 production Source: UniProtKB
Negative regulation of lipid biosynthetic process Source: UniProtKB
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: UniProtKB
Negative regulation of platelet aggregation Source: UniProtKB
Negative regulation of protein kinase activity Source: UniProtKB
Negative regulation of T cell mediated cytotoxicity Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Negative regulation of vascular permeability Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of vasculogenesis Source: UniProtKB
Regulation of blood vessel remodeling Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of cell migration Source: UniProtKB
Regulation of endothelial cell differentiation Source: UniProtKB
Regulation of endothelial cell migration Source: UniProtKB
Regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB
Regulation of homophilic cell adhesion Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Regulation of sprouting angiogenesis Source: UniProtKB
wound healing, spreading of cells Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane; Lateral cell membrane; Apical cell membrane; Basal cell membrane; Cell junction; Adherens junction. Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes.
Isoform 2&3&4: Secreted
Isoform 5&6&7: Cell membrane
Isoform 8: Cell membrane; Lateral cell membrane; Apical cell membrane; Basal cell membrane; Secretory vesicle membrane; Cell junction; Adherens junction. Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961).
Microvillus membrane; Apical cell membrane. Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells.
Topology
Extracellular: 35-428
Helical: 429-452
Cytoplasmic: 453-526
PTM
Isoform 1:
Phosphorylated on serine and tyrosine (By similarity). Isoform 1 is phosphorylated on tyrosine by Src family kinases like SRC and LCK and by receptor like CSF3R, EGFR and INSR upon stimulation (PubMed:15467833, PubMed:18424730, PubMed:7478590). Phosphorylated at Ser-508; mediates activity. Phosphorylated at Tyr-493; regulates activity (By similarity). Phosphorylated at Tyr-493 by EGFR and INSR upon stimulation; this phosphorylation is Ser-508-phosphorylation-dependent; mediates cellular internalization; increases interaction with downstream proteins like SHC1 and FASN (By similarity). Phosphorylated at Tyr-493 and Tyr-520 by LCK; mediates PTPN6 association and is regulated by homophilic ligation of CEACAM1 in the absence of T cell activation (PubMed:18424730). Phosphorylated at Tyr-520; mediates interaction with PTPN11 (By similarity).
Isoform 8:
Phosphorylated on serine and threonine.

Anti-CEACAM1 antibodies

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Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: F7
Application*: ELISA, FC, IHC, IP
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP480
Application*: ICC, IHC, IP, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP479
Application*: ICC, IHC, IP, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 161
Application*: ELISA, IP, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C6G9
Application*: IHC, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Cocktail
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PARLAM 4
Application*: FC, ICC, IHC, WB
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Arcitumomab
Application*: FC, IHC
Target: CEACAM1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: Arcitumomab
Application*: FC, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: SPM330
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C66/261
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: C66/195
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C66/1260
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM584
Application*: FC, IF, IHC, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2755
Application*: E, WB, IH
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C5-1X
Application*: WB, F, E, IH, IF, MC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CEA-9
Application*: WB, IH, IP, P
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1822
Application*: F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0357
Application*: E, P, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0358
Application*: E
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1060
Application*: F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1675
Application*: E, IP, R
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1674
Application*: F, IC, IF
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1673
Application*: P
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1672
Application*: E
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYC-1671
Application*: F, E, IH, IP, IF
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1670
Application*: E, IH, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1669
Application*: E, P, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0499
Application*: F, WB
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0216
Application*: F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0043
Application*: F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: 11-1H
Application*: F, E, IH, IP, IF
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: COL-1
Application*: FC, IF, IHC, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C66/1030
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: SPM506
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C66/1009
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: SPM541
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CEA31
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM551
Application*: FC, IF, IHC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP418
Application*: IHC
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR090G
Application*: WB, IP, IHC, ICC
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR032F
Application*: WB, IP, IHC, ICC
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D3R8O
Application*: WB, P
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D1P4T
Application*: WB, IP
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CC1
Application*: WB, F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: MAb-CC1
Application*: F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-D60
Application*: FC
Target: CEACAM1
Host: Mouse
Specificity: Frog, Rat
Clone: F7
Application*: E, F, IH, IP, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B3-17
Application*: E, F, IH, IP, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TET2
Application*: WB, IP, E, C, F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1838
Application*: C, E, IF, F
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C1837
Application*: WB
Target: CEACAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 723629
Application*: F, C, WB
Target: CEACAM1
Host: Mouse
Specificity: Human
Clone: CBYY-C0364
Application*: E, F, IH
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 05
Application*: E
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 030
Application*: P
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 025
Application*: E
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 117
Application*: F, IC/IF, IF
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G5
Application*: C, E, IC/IF, F
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8B6E2F4
Application*: E, P
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6
Application*: E
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3H9L7
Application*: WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F9
Application*: E
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F6
Application*: E, P, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F10
Application*: E
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 29H2
Application*: P
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 28T25
Application*: E, C, WB
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1105
Application*: E, IP, R
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 003
Application*: EC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 283340
Application*: WB, F, MC
Target: CEACAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 283324
Application*: WB, IH, EC
Target: CEACAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 103
Application*: F, IC/IF, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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