Cynomolgus Recombinant CNTN1 protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY1476)

Name: Cynomolgus Recombinant CNTN1 protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY1476
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His & AVI Tag

Protein Construction

This product is Cynomolgus Recombinant CNTN1 protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-993 and predicts a molecular mass of 111.67 kDa.

Molecule Mass

111.67 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-993

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, TCEP, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Contactin 1

Function

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).

Biological Process

Cell adhesion Source: ProtInc
Cerebellum development Source: Ensembl
Neuron projection development Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Myopathy, congenital, Compton-North (MYPCN):
A lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.

Pascual-Goñi, E., Fehmi, J., Lleixà, C., Martín-Aguilar, L., Devaux, J., Höftberger, R., ... & Querol, L. (2021). Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. Brain, 144(4), 1183-1196.

Wieske, L., Martín-Aguilar, L., Fehmi, J., Lleixà, C., Koel-Simmelink, M. J., Chatterjee, M., ... & Eftimov, F. (2021). Serum contactin-1 in CIDP: A cross-sectional study. Neurology-Neuroimmunology Neuroinflammation, 8(5).

Zhang, M., Yu, Q., Tang, W., Wu, Y., Lv, J., Sun, L., ... & Xia, Z. (2021). Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell–dominant T-cell responses in asthma. Journal of Allergy and Clinical Immunology, 148(6), 1545-1558.

Cortese, A., Lombardi, R., Briani, C., Callegari, I., Benedetti, L., Manganelli, F., ... & Franciotta, D. (2020). Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: clinical relevance of IgG isotype. Neurology-Neuroimmunology Neuroinflammation, 7(1).

Gu, Y., Li, T., Kapoor, A., Major, P., & Tang, D. (2020). Contactin 1: An important and emerging oncogenic protein promoting cancer progression and metastasis. Genes, 11(8), 874.

Fehmi, J., Davies, A. J., Antonelou, M., Teunissen, C. E., Keddie, S., Pikkupeura, S., ... & Rinaldi, S. (2020). Contactin-1 antibodies link autoimmune neuropathies to nephrotic syndrome.

Veny, M., Grases, D., Kucharova, K., Lin, W. W., Nguyen, J., Huang, S., ... & Šedý, J. R. (2020). Contactin-1 is required for peripheral innervation and immune homeostasis within the intestinal mucosa. Frontiers in Immunology, 11, 1268.

Chen, N., He, S., Geng, J., Song, Z. J., Han, P. H., Qin, J., ... & Dang, C. X. (2018). Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells. BMC cell biology, 19(1), 1-8.

Chen, Y. A., Lu, I., & Tsai, J. W. (2018). Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Frontiers in molecular neuroscience, 422.

Ocklenburg, S., Gerding, W. M., Arning, L., Genç, E., Epplen, J. T., Güntürkün, O., & Beste, C. (2017). Myelin genes and the corpus callosum: proteolipid protein 1 (PLP1) and contactin 1 (CNTN1) gene variation modulates interhemispheric integration. Molecular Neurobiology, 54(10), 7908-7916.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY3341)

Mouse Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY8150)

Rat Cntn1 ELISA Kit (CAT#: V2LY-0626-LY2154)

Related Products

Mouse Anti-CNTN1 Recombinant Antibody (CBLG1-359) (CAT#: V2LY-1206-LY528)

Mouse Anti-CNTN1 Recombinant Antibody (CBLNC-148) (CAT#: CBMAB-1407-CN)

Human Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY3341)

Mouse Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY8150)

Rat Cntn1 ELISA Kit (CAT#: V2LY-0626-LY2154)

Mouse Anti-CNTN1 Recombinant Antibody (CBLG1-360) (CAT#: V2LY-1206-LY529)

Mouse Anti-CNTN1 Recombinant Antibody (CBFYC-2016) (CAT#: V2LY-1206-LY530)

Rabbit Anti-CNTN1 Recombinant Antibody (CP0338) (CAT#: V2LY-1206-LY531)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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