Rat Cntn1 ELISA Kit (V2LY-0626-LY2154)

Name: Rat Cntn1 ELISA Kit
SKU: V2LY-0626-LY2154
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.048 ng/mL

Detection Range

0.1-40 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

113.5 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Contactin 1

Function

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).

Biological Process

Cell adhesion Source: ProtInc
Cerebellum development Source: Ensembl
Neuron projection development Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Myopathy, congenital, Compton-North (MYPCN):
A lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.

Pascual-Goñi, E., Fehmi, J., Lleixà, C., Martín-Aguilar, L., Devaux, J., Höftberger, R., ... & Querol, L. (2021). Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. Brain, 144(4), 1183-1196.

Wieske, L., Martín-Aguilar, L., Fehmi, J., Lleixà, C., Koel-Simmelink, M. J., Chatterjee, M., ... & Eftimov, F. (2021). Serum contactin-1 in CIDP: A cross-sectional study. Neurology-Neuroimmunology Neuroinflammation, 8(5).

Zhang, M., Yu, Q., Tang, W., Wu, Y., Lv, J., Sun, L., ... & Xia, Z. (2021). Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell–dominant T-cell responses in asthma. Journal of Allergy and Clinical Immunology, 148(6), 1545-1558.

Cortese, A., Lombardi, R., Briani, C., Callegari, I., Benedetti, L., Manganelli, F., ... & Franciotta, D. (2020). Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: clinical relevance of IgG isotype. Neurology-Neuroimmunology Neuroinflammation, 7(1).

Gu, Y., Li, T., Kapoor, A., Major, P., & Tang, D. (2020). Contactin 1: An important and emerging oncogenic protein promoting cancer progression and metastasis. Genes, 11(8), 874.

Fehmi, J., Davies, A. J., Antonelou, M., Teunissen, C. E., Keddie, S., Pikkupeura, S., ... & Rinaldi, S. (2020). Contactin-1 antibodies link autoimmune neuropathies to nephrotic syndrome.

Veny, M., Grases, D., Kucharova, K., Lin, W. W., Nguyen, J., Huang, S., ... & Šedý, J. R. (2020). Contactin-1 is required for peripheral innervation and immune homeostasis within the intestinal mucosa. Frontiers in Immunology, 11, 1268.

Chen, N., He, S., Geng, J., Song, Z. J., Han, P. H., Qin, J., ... & Dang, C. X. (2018). Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells. BMC cell biology, 19(1), 1-8.

Chen, Y. A., Lu, I., & Tsai, J. W. (2018). Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Frontiers in molecular neuroscience, 422.

Ocklenburg, S., Gerding, W. M., Arning, L., Genç, E., Epplen, J. T., Güntürkün, O., & Beste, C. (2017). Myelin genes and the corpus callosum: proteolipid protein 1 (PLP1) and contactin 1 (CNTN1) gene variation modulates interhemispheric integration. Molecular Neurobiology, 54(10), 7908-7916.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CNTN1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1476)

Human Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY3341)

Mouse Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY8150)

Related Products

Human Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY3341)

Mouse Anti-CNTN1 Recombinant Antibody (CBLG1-359) (CAT#: V2LY-1206-LY528)

Mouse Anti-CNTN1 Recombinant Antibody (CBFYC-2016) (CAT#: V2LY-1206-LY530)

Mouse Recombinant CNTN1 protein, His Tag (CAT#: V2LY-0526-LY8150)

Cynomolgus Recombinant CNTN1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1476)

Mouse Anti-CNTN1 Recombinant Antibody (CBLNC-148) (CAT#: CBMAB-1407-CN)

Mouse Anti-CNTN1 Recombinant Antibody (CBLG1-360) (CAT#: V2LY-1206-LY529)

Rabbit Anti-CNTN1 Recombinant Antibody (CP0338) (CAT#: V2LY-1206-LY531)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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