Cynomolgus, Rhesus Recombinant CD83 protein, His Tag (V2LY-0526-LY1695)

Name: Cynomolgus, Rhesus Recombinant CD83 protein, His Tag
SKU: V2LY-0526-LY1695
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus, Rhesus

Tag

His Tag

Protein Construction

This product is Cynomolgus, Rhesus Recombinant CD83 protein, His Tag consist of Amino Acid: 1-143 and predicts a molecular mass of 15.4 kDa.

Molecule Mass

15.4 kDa

Sequence

Amino Acid: 1-143

Species

Cynomolgus, Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol, Arg, Tween20

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD83 Molecule

Function

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Biological Process

Defense response Source: ProtInc
Humoral immune response Source: ProtInc
Negative regulation of interleukin-4 production Source: Ensembl
Positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of interleukin-2 production Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Membrane

Topology

Extracellular: 20-144
Helical: 145-166
Cytoplasmic: 167-205

Shrestha, A., Sadeyen, J. R., Lukosaityte, D., Chang, P., Smith, A., Van Hulten, M., & Iqbal, M. (2021). Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza. npj Vaccines, 6(1), 1-12.

Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A. B., Zinser, E., ... & Lechmann, M. (2020). The CD83 Molecule–An Important Immune Checkpoint. Frontiers in immunology, 11, 721.

Batool, A., Liu, H., Liu, Y. X., & Chen, S. R. (2020). CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate. Cancers, 12(8), 2269.

Islam, S. M., Byun, H. O., Choi, B., & Sohn, S. (2019). Inhibition of CD83 alleviates systemic inflammation in herpes simplex virus type 1-induced Behcet’s disease model mouse. Mediators of inflammation, 2019.

Zinser, E., Naumann, R., Wild, A. B., Michalski, J., Deinzer, A., Stich, L., ... & Knippertz, I. (2019). Endogenous expression of the human CD83 attenuates EAE symptoms in humanized transgenic mice and increases the activity of regulatory T cells. Frontiers in immunology, 10, 1442.

Nombela, I., Requena-Platek, R., Morales-Lange, B., Chico, V., Puente-Marin, S., Ciordia, S., ... & Ortega-Villaizan, M. D. M. (2019). Rainbow trout red blood cells exposed to viral hemorrhagic septicemia virus up-regulate antigen-processing mechanisms and MHC I&II, CD86, and CD83 antigen-presenting cell markers. Cells, 8(5), 386.

Wild, A. B., Krzyzak, L., Peckert, K., Stich, L., Kuhnt, C., Butterhof, A., ... & Steinkasserer, A. (2019). CD83 orchestrates immunity toward self and non-self in dendritic cells. JCI insight, 4(20).

Huo, S., Zhang, J., Wu, F., Zuo, Y., Cui, D., Li, X., ... & Zhong, F. (2019). Porcine CD83 is a glycosylated dimeric protein existing naturally in membrane-bound and soluble forms. Developmental & Comparative Immunology, 90, 60-69.

Lin, W., Buscher, K., Wang, B., Fan, Z., Song, N., Li, P., ... & Bi, H. (2018). Soluble CD83 alleviates experimental autoimmune uveitis by inhibiting filamentous actin-dependent calcium release in dendritic cells. Frontiers in immunology, 9, 1567.

Mo, Z. Q., Wang, J. L., Yang, M., Ni, L. Y., Wang, H. Q., Lao, G. F., ... & Dan, X. M. (2017). Characterization and expression analysis of grouper (Epinephelus coioides) co-stimulatory molecules CD83 and CD80/86 post Cryptocaryon irritans infection. Fish & shellfish immunology, 67, 467-474.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD83 protein, hFc Tag (CAT#: V2LY-0526-LY1694)

Human Recombinant CD83 protein, His Tag (CAT#: V2LY-0526-LY2967)

Mouse Recombinant CD83 protein, hFc Tag (CAT#: V2LY-0526-LY8076)

Mouse Recombinant CD83 protein, His Tag (CAT#: V2LY-0526-LY8077)

Rat Recombinant CD83 protein, hFc Tag (CAT#: V2LY-0526-LY9273)

Rat Recombinant CD83 protein, His Tag (CAT#: V2LY-0526-LY9274)

Related Products

Mouse Recombinant CD83 protein, hFc Tag (CAT#: V2LY-0526-LY8076)

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Mouse Anti-CD83 Recombinant Antibody (CBYY-C1599) (CAT#: CBMAB-C3037-YY)

Mouse Anti-CD83 Recombinant Antibody (3G10-1F4) (CAT#: CBMAB-C6100-LY)

Mouse Recombinant CD83 protein, His Tag (CAT#: V2LY-0526-LY8077)

Mouse Anti-CD83 Recombinant Antibody (HB15) (CAT#: CBMAB-C1765-CQ)

Rabbit Anti-CD83 Recombinant Antibody (CBFYC-1457) (CAT#: CBMAB-C1515-FY)

Rat Recombinant CD83 protein, hFc Tag (CAT#: V2LY-0526-LY9273)

Human Recombinant CD83 protein, His Tag (CAT#: V2LY-0526-LY2967)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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