CD83 Antibodies

Structure of CD83

CD83 is a cell surface glycoprotein with a molecular weight of approximately 45-50 kDa. The specific molecular weight varies depending on the degree of glycosylation modification.

The CD83 protein is composed of 244 amino acids, and its extracellular region contains two immunoglobulin-like domains (type V and type C2), which form a stable spatial conformation through disulfide bonds. The transmembrane region of this protein anchors it to the cell membrane, while the shorter intracellular region is involved in signal transduction. The glycosylation modifications of CD83 mainly occur on the asparagine residues in the extracellular region, and these glycosylation modifications affect the stability and function of the protein.

Fig. 1 Atomic structure of CD83.¹

Key structural properties of CD83:

• Extracellular region contains two immune globulin structure domain (V and C2)
• Multiple conserved cysteine residues form intramolecular disulfide bonds
• Transmembrane regions anchor proteins to cell membranes
• Intracellular segments contain potential phosphorylation sites involved in signal transduction
• Glycosylation modification sites were mainly located in the extracellular region

Functions of CD83

The main function of CD83 is to participate in the regulation of immune responses, especially playing a key role in the maturation of dendritic cells and the activation of T cells. In addition, this molecule is also involved in the establishment and maintenance of immune tolerance.

The immunomodulatory properties of CD83 exhibit dose-dependent characteristics. Its membrane form and soluble form respectively exert positive and negative regulatory functions. This dual mechanism makes it an important target for immune checkpoint research.

Applications of CD83 and CD83 Antibody in Literature

1. Riaz, Bushra, et al. "CD83 regulates the immune responses in inflammatory disorders." International Journal of Molecular Sciences 24.3 (2023): 2831. https://doi.org/10.3390/ijms24032831

Research has found that CD83 is a key molecule for the maturation of dendritic cells and participates in immune responses by regulating T cell differentiation. Its role in autoimmune diseases and pathogen immune escape remains unclear. This article reviews the function of CD83 in inflammatory diseases.

2. Grosche, Linda, et al. "The CD83 molecule–an important immune checkpoint." Frontiers in Immunology 11 (2020): 721. https://doi.org/10.3389/fimmu.2020.00721

Research has found that CD83 is expressed in a variety of immune cells. It is not only a co-stimulatory molecule but also plays a key role in controlling immune responses, maintaining immune tolerance and inflammatory balance. Its immunomodulatory function shows great therapeutic potential.

3. Li, Ziduo, et al. "CD83: activation marker for antigen presenting cells and its therapeutic potential." Frontiers in immunology 10 (2019): 1312. https://doi.org/10.3389/fimmu.2019.01312

Research has found that CD83 is a key immunomodulatory molecule. Membrane-type CD83 promotes immune activation, while soluble CD83 has immunosuppressive functions. Therapies based on this characteristic (such as sCD83 or anti-CD83 antibodies) have shown great potential in the treatment of autoimmune diseases, transplant rejection and other diseases.

4. Wu, Zhiwen, et al. "CD83 expression characterizes precursor exhausted T cell population." Communications biology 6.1 (2023): 258. https://doi.org/10.1038/s42003-023-04631-6

Research has found that CD83 can serve as a specific surface marker for precursor exhausted T cells (TPEX) in tumor-infiltrating T cells, effectively distinguishing between terminal exhausted T cells and bystander T cells, and has stronger proliferation and anti-tumor capabilities.

5. Akauliya, Madhav, et al. "CD83 expression regulates antibody production in response to influenza A virus infection." Virology Journal 17.1 (2020): 194. https://doi.org/10.1186/s12985-020-01465-0

Research has found that CD83 is crucial in influenza A virus infection. CD83 gene knockout mice exhibited dysregulation of B cell and T cell homeostasis and were unable to produce effective virus-specific IgG antibodies, revealing the crucial role of CD83 in antiviral immunity.

Creative Biolabs: CD83 Antibodies for Research

Creative Biolabs specializes in the production of high-quality CD83 antibodies for research and industrial applications. Our portfolio includes monoclonal antibodies tailored for ELISA, Flow Cytometry, Western blot, immunohistochemistry, and other diagnostic methodologies.

• Custom CD83 Antibody Development: Tailor-made solutions to meet specific research requirements.
• Bulk Production: Large-scale antibody manufacturing for industry partners.
• Technical Support: Expert consultation for protocol optimization and troubleshooting.
• Aliquoting Services: Conveniently sized aliquots for long-term storage and consistent experimental outcomes.

For more details on our CD83 antibodies, custom preparations, or technical support, contact us at email.