Rabbit Anti-CD83 Recombinant Antibody (CBFYC-1454) (CBMAB-C1512-FY)

Name: Rabbit Anti-CD83 Recombinant Antibody (CBFYC-1454)
SKU: CBMAB-C1512-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYC-1454

Application

Immunogen

Recombinant Human CD83 Protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	1:25-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD83 Molecule

Introduction

CD83 (CD83 Molecule) is a Protein Coding gene. Diseases associated with CD83 include Plague and Rift Valley Fever. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T cell receptor signaling pathway.

Entrez Gene ID

12522

UniProt ID

O88324

Alternative Names

CD83 antigen; mCD83

Function

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Biological Process

Defense response Source: ProtInc
Humoral immune response Source: ProtInc
Negative regulation of interleukin-4 production Source: Ensembl
Positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of interleukin-2 production Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Membrane

Topology

Extracellular: 20-144
Helical: 145-166
Cytoplasmic: 167-205

Shrestha, A., Sadeyen, J. R., Lukosaityte, D., Chang, P., Smith, A., Van Hulten, M., & Iqbal, M. (2021). Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza. npj Vaccines, 6(1), 1-12.

Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A. B., Zinser, E., ... & Lechmann, M. (2020). The CD83 Molecule–An Important Immune Checkpoint. Frontiers in immunology, 11, 721.

Batool, A., Liu, H., Liu, Y. X., & Chen, S. R. (2020). CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate. Cancers, 12(8), 2269.

Islam, S. M., Byun, H. O., Choi, B., & Sohn, S. (2019). Inhibition of CD83 alleviates systemic inflammation in herpes simplex virus type 1-induced Behcet’s disease model mouse. Mediators of inflammation, 2019.

Zinser, E., Naumann, R., Wild, A. B., Michalski, J., Deinzer, A., Stich, L., ... & Knippertz, I. (2019). Endogenous expression of the human CD83 attenuates EAE symptoms in humanized transgenic mice and increases the activity of regulatory T cells. Frontiers in immunology, 10, 1442.

Nombela, I., Requena-Platek, R., Morales-Lange, B., Chico, V., Puente-Marin, S., Ciordia, S., ... & Ortega-Villaizan, M. D. M. (2019). Rainbow trout red blood cells exposed to viral hemorrhagic septicemia virus up-regulate antigen-processing mechanisms and MHC I&II, CD86, and CD83 antigen-presenting cell markers. Cells, 8(5), 386.

Wild, A. B., Krzyzak, L., Peckert, K., Stich, L., Kuhnt, C., Butterhof, A., ... & Steinkasserer, A. (2019). CD83 orchestrates immunity toward self and non-self in dendritic cells. JCI insight, 4(20).

Huo, S., Zhang, J., Wu, F., Zuo, Y., Cui, D., Li, X., ... & Zhong, F. (2019). Porcine CD83 is a glycosylated dimeric protein existing naturally in membrane-bound and soluble forms. Developmental & Comparative Immunology, 90, 60-69.

Lin, W., Buscher, K., Wang, B., Fan, Z., Song, N., Li, P., ... & Bi, H. (2018). Soluble CD83 alleviates experimental autoimmune uveitis by inhibiting filamentous actin-dependent calcium release in dendritic cells. Frontiers in immunology, 9, 1567.

Mo, Z. Q., Wang, J. L., Yang, M., Ni, L. Y., Wang, H. Q., Lao, G. F., ... & Dan, X. M. (2017). Characterization and expression analysis of grouper (Epinephelus coioides) co-stimulatory molecules CD83 and CD80/86 post Cryptocaryon irritans infection. Fish & shellfish immunology, 67, 467-474.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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