DNMT3L Matched Antibody Pair (351) (APMAB-351LY)

Name: DNMT3L Matched Antibody Pair (351)
SKU: APMAB-351LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-DNMT3L polyclonal antibody, 100 ug

Detection Antibody

Anti-DNMT3L Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Alternative Names

DNA Methyltransferase 3 Like; Cytosine-5-Methyltransferase 3-Like Protein; DNA (Cytosine-5-)-Methyltransferase 3-Like;

Entrez Gene ID

29947

UniProt ID

Q9UJW3

More Infomation

Laufer, B. I., Gomez, J. A., Jianu, J. M., & LaSalle, J. M. (2021). Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature. Epigenetics & chromatin, 14(1), 1-15.

Flitton, M., Rielly, N., Warman, R., Warden, D., Smith, A. D., Macdonald, I. A., & Knight, H. M. (2019). Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline. Neurobiology of Aging, 78, 64-73.

Heo, J., Lim, J., Lee, S., Jeong, J., Kang, H., Kim, Y., ... & Shin, D. M. (2017). Sirt1 regulates DNA methylation and differentiation potential of embryonic stem cells by antagonizing Dnmt3l. Cell reports, 18(8), 1930-1945.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DNMT3L, Active protein, GST Tag (CAT#: V2LY-0526-LY3614)

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Mouse Anti-DNMT3L Recombinant Antibody (CBT3801) (CAT#: V2LY-0625-LY417)

Mouse Anti-DNMT3L Recombinant Antibody (D1439) (CAT#: V2LY-0425-LY738)

Rabbit Anti-DNMT3L Recombinant Antibody (D1443) (CAT#: V2LY-0425-LY741)

Human Recombinant DNMT3L, Active protein, GST Tag (CAT#: V2LY-0526-LY3614)

Mouse Anti-DNMT3L Monoclonal Antibody (1D5) (CAT#: CBMAB-0299-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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