Human Recombinant DNMT3L, Active protein, GST Tag (V2LY-0526-LY3614)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327).
Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327).
Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327).
Plays a key role in embryonic stem cells and germ cells (By similarity).
In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity).
In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity).
Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity).
While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity).
Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity).
Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).
DNA methylation involved in gamete generation Source: UniProtKB
DNA methylation on cytosine Source: UniProtKB
Male meiosis I Source: UniProtKB
Negative regulation of DNA methylation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of DNA methylation Source: UniProtKB
Regulation of gene expression by genetic imprinting Source: UniProtKB
Spermatogenesis Source: UniProtKB
Stem cell differentiation Source: UniProtKB
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
DNMT3L Matched Antibody Pair (351) (CAT#: APMAB-351LY)
Antibody Pairs
DNMT3L Matched Antibody Pair (351) (CAT#: APMAB-351LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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