Human BMP10 ELISA Kit (V2LY-0626-LY2614)

Name: Human BMP10 ELISA Kit
SKU: V2LY-0626-LY2614
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.011 ng/mL

Detection Range

0.02-4.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

48.0 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Bone Morphogenetic Protein 10

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Biological Process

Activin receptor signaling pathway Source: BHF-UCL
Adult heart development Source: BHF-UCL
Atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
BMP signaling pathway Source: BHF-UCL
Cardiac muscle cell proliferation Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Heart trabecula formation Source: BHF-UCL
Kidney development Source: Ensembl
Negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of endothelial cell migration Source: BHF-UCL
Pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
Positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
Positive regulation of cartilage development Source: Ensembl
Positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of sarcomere organization Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
SMAD protein signal transduction Source: GO_Central
Ventricular cardiac muscle cell development Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

Cellular Location

Secreted

Owen, N. E., Nyimanu, D., Kuc, R. E., Upton, P. D., Morrell, N. W., Alexander, G. J., ... & Davenport, A. P. (2021). Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10. Peptides, 136, 170440.

Hu, Y., Yu, L., Xia, F., Liang, F., Cheng, C., Huang, Y., & Xiao, L. (2021). Expression of bone morphogenetic protein 10 in cases with endometrial carcinoma and its clinical significance. Clinical and Translational Oncology, 1-6.

Hirono, K., Saito, K., Munkhsaikhan, U., Xu, F., Wang, C., Lu, L., ... & Purevjav, E. (2019). Familial left ventricular non-compaction is associated with a rare p. V407I variant in bone morphogenetic protein 10. Circulation Journal, 83(8), 1737-1746.

Jin, Y., Zheng, W., Li, L., Huang, G., Liu, Y., Jiang, H., ... & Tang, C. (2019). Loss of BMP-10 is correlated with poor survival in ovarian cancer. Pathology-Research and Practice, 215(1), 121-126.

Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K. C., Guihard, P. J., Cubberly, M. R., ... & Boström, K. I. (2018). Combined effects of bone morphogenetic protein 10 and crossveinless‐2 on cardiomyocyte differentiation in mouse adipocyte‐derived stem cells. Journal of cellular physiology, 233(3), 1812-1822.

Tillet, E., Ouarné, M., Desroches-Castan, A., Mallet, C., Subileau, M., Didier, R., ... & Bailly, S. (2018). A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. Journal of Biological Chemistry, 293(28), 10963-10974.

Mitrofan, C. G., Appleby, S. L., Nash, G. B., Mallat, Z., Chilvers, E. R., Upton, P. D., & Morrell, N. W. (2017). Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. Journal of Biological Chemistry, 292(33), 13714-13726.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Bmp10 ELISA Kit (CAT#: V2LY-0626-LY1871)

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Mouse Anti-BMP10 Recombinant Antibody (CBYY-0657) (CAT#: CBMAB-0660-YY)

Rat Bmp10 ELISA Kit (CAT#: V2LY-0626-LY1871)

Mouse Anti-BMP10 Recombinant Antibody (Iv0061) (CAT#: CBMAB-AP653LY)

Rat Anti-BMP10 Recombinant Antibody (CBYY-1858) (CAT#: CBMAB-2207-YY)

Mouse Anti-BMP10 Recombinant Antibody (EG400) (CAT#: CBMAB-EN448-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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