BMP10

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]

Full Name

Bone Morphogenetic Protein 10

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Biological Process

Activin receptor signaling pathway Source: BHF-UCL
Adult heart development Source: BHF-UCL
Atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
BMP signaling pathway Source: BHF-UCL
Cardiac muscle cell proliferation Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Heart trabecula formation Source: BHF-UCL
Kidney development Source: Ensembl
Negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of endothelial cell migration Source: BHF-UCL
Pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
Positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
Positive regulation of cartilage development Source: Ensembl
Positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of sarcomere organization Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
SMAD protein signal transduction Source: GO_Central
Ventricular cardiac muscle cell development Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

Cellular Location

Secreted