Human ACSL1 ELISA Kit (V2LY-0626-LY4826)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0093 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
77.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
acyl-CoA synthetase long-chain family member 1
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Alpha-linolenic acid metabolic process
Fatty acid transport
Linoleic acid metabolic process
Lipid biosynthetic process
Long-chain fatty acid import into cell
Long-chain fatty acid metabolic process
Long-chain fatty-acyl-CoA biosynthetic process
Positive regulation of cold-induced thermogenesis
Positive regulation of long-chain fatty acid import across plasma membrane
Positive regulation of protein serine/threonine kinase activity
Regulation of metabolic process
Response to drug
Response to nutrient
Response to oleic acid
Response to organic cyclic compound
Triglyceride biosynthetic process
Very long-chain fatty acid metabolic process
Xenobiotic catabolic process
Cellular Location
Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane; Mitochondrion outer membrane
Topology
Helical: 25-45 aa
Cytoplasmic: 46-698 aa

Dykstra, H., Fisk, C., LaRose, C., Waldhart, A., Meng, X., Zhao, G., & Wu, N. (2021). Mouse long-chain acyl-CoA synthetase 1 is active as a monomer. Archives of Biochemistry and Biophysics, 700, 108773.

Li, B., Liu, J., Xin, X., Zhang, L., Zhou, J., Xia, C., ... & Yu, H. (2021). MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression. International Journal of Medical Sciences, 18(3), 615.

Huh, J. Y., Reilly, S. M., Abu-Odeh, M., Murphy, A. N., Mahata, S. K., Zhang, J., ... & Saltiel, A. R. (2020). TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metabolism, 32(6), 1012-1027.

Guo, L., Lu, J., Gao, J., Li, M., Wang, H., & Zhan, X. (2020). The function of SNHG7/miR‐449a/ACSL1 axis in thyroid cancer. Journal of cellular biochemistry, 121(10), 4034-4042.

Singh, A. B., Dong, B., Xu, Y., Zhang, Y., & Liu, J. (2019). Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1864(3), 358-371.

Roelands, J., Garand, M., Hinchcliff, E., Ma, Y., Shah, P., Toufiq, M., ... & Chaussabel, D. (2019). Long-chain acyl-CoA synthetase 1 role in sepsis and immunity: perspectives from a parallel review of public transcriptome datasets and of the literature. Frontiers in immunology, 10, 2410.

Yang, G., Wang, Y., Feng, J., Liu, Y., Wang, T., Zhao, M., ... & Zhang, X. (2017). Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochemical and biophysical research communications, 486(3), 827-832.

Wang, Y., Cai, X., Zhang, S., Cui, M., Liu, F., Sun, B., ... & Ye, L. (2017). HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochemical and biophysical research communications, 484(3), 565-571.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Acsl1 ELISA Kit (CAT#: V2LY-0626-LY2547)

Related Products

Rabbit Anti-ACSL1 Recombinant Antibody (V2-179443) (CAT#: CBMAB-A0750-YC)

Mouse Acsl1 ELISA Kit (CAT#: V2LY-0626-LY2547)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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