Human CD79B ELISA Kit (V2LY-0626-LY5504)

Name: Human CD79B ELISA Kit
SKU: V2LY-0626-LY5504
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0014 ng/mL

Detection Range

0.003-0.9 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

26.0 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

CD79b Molecule

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell differentiation Source: GO_Central
B cell receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Involvement in disease

Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Topology

Extracellular: 29-159
Helical: 160-180
Cytoplasmic: 181-229

PTM

Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Cheng, G. F., Kong, W. G., Zhai, X., Mu, Q. J., Dong, Z. R., Zhan, M. T., & Xu, Z. (2021). Molecular cloning and expression analysis of CD79a and CD79b in rainbow trout (Oncorhynchus mykiss) after bacterial, parasitic, and viral infection. Fish & Shellfish Immunology, 118, 385-395.

Camus, V., & Tilly, H. (2020). Polatuzumab vedotin, an anti-CD79b antibody–drug conjugate for the treatment of relapsed/refractory diffuse large B-cell lymphoma. Future Oncology, 17(2), 127-135.

Bourbon, E., & Salles, G. (2020). Polatuzumab vedotin: an investigational anti-CD79b antibody drug conjugate for the treatment of diffuse large B-cell lymphoma. Expert Opinion on Investigational Drugs, 29(10), 1079-1088.

Ding, S., Mao, X., Cao, Y., Wang, N., Xu, H., & Zhou, J. (2020). Targeting CD79b for chimeric antigen receptor T-cell therapy of B-cell lymphomas. Targeted Oncology, 15, 365-375.

Li, D., Lee, D., Dere, R. C., Zheng, B., Yu, S. F., Fuh, F. K., ... & Prabhu, S. (2019). Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin. British journal of pharmacology, 176(19), 3805-3818.

Schrader, A. M., Jansen, P. M., Willemze, R., Vermeer, M. H., Cleton-Jansen, A. M., Somers, S. F., ... & Vermaat, J. S. (2018). High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma. Blood, The Journal of the American Society of Hematology, 131(18), 2086-2089.

Li, H., Li, Y., Zhang, X., Wang, Y., Zhang, W., Wu, X., & Wang, Z. (2017). Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus). Fish physiology and biochemistry, 43(6), 1571-1585.

Chen, W., Shankar, S., Lohr, J., Yao, X. T., Li, H., Chen, X., ... & Wigginton, J. (2017). SAT0027 Immunomodulatory effects of MGD010, a dart® molecule targeting human B-CELL CD32B and CD79B.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD79B protein, ECD, His Tag (CAT#: V2LY-0526-LY1692)

Human Recombinant CD79B protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2948)

Human Recombinant CD79B protein, ECD, His Tag (CAT#: V2LY-0526-LY2949)

Human Recombinant CD79B protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2950)

Human Recombinant CD79B protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY2951)

Mouse Recombinant CD79B protein, His Tag (CAT#: V2LY-0526-LY8070)

Rat Recombinant CD79B protein, hFc Tag (CAT#: V2LY-0526-LY9268)

Rat Recombinant CD79B protein, His Tag (CAT#: V2LY-0526-LY9269)

Mouse Cd79b ELISA Kit (CAT#: V2LY-0626-LY2064)

CD79B Matched Antibody Pair (235) (CAT#: APMAB-235LY)

Antibody Pairs

CD79B Matched Antibody Pair (235) (CAT#: APMAB-235LY)

Related Products

Rabbit Anti-CD79B Recombinant Antibody (C10618) (CAT#: CBMAB-C10618-LY)

Mouse Anti-CD79B Recombinant Antibody (CBXC-0268) (CAT#: CBMAB-C4985-CQ)

Mouse Anti-CD79B Recombinant Antibody (CBYY-C0139) (CAT#: CBMAB-C0482-YY)

Mouse Anti-CD79B Recombinant Antibody (CBT4037) (CAT#: V2LY-0625-LY1012)

Human Recombinant CD79B protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2948)

Human Recombinant CD79B protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2950)

Mouse Anti-CD79B Recombinant Antibody (C0416) (CAT#: CBMAB-C0416-CQ)

Human Recombinant CD79B protein, ECD, His Tag (CAT#: V2LY-0526-LY2949)

Rabbit Anti-CD79B Recombinant Antibody (CP0226) (CAT#: CBMAB-CP0226-LY)

CD79B Matched Antibody Pair (235) (CAT#: APMAB-235LY)

Isotype control

For research use only. Not intended for any clinical use.

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