Human Recombinant CD79B protein, PE Conjugated, His Tag (V2LY-0526-LY2951)

Name: Human Recombinant CD79B protein, PE Conjugated, His Tag
SKU: V2LY-0526-LY2951
Rating: 5 (1 reviews)

See all CD79B antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CD79B protein, PE Conjugated, His Tag consist of Amino Acid: 1-159 and predicts a molecular mass of 18.5 kDa.

Molecule Mass

18.5 kDa

Conjugates

Sequence

Amino Acid: 1-159

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Twelve months from date of receipt at -20°C to -70°C in lyophilized form and 3 months at -70°C under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD79b Molecule

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell differentiation Source: GO_Central
B cell receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Involvement in disease

Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Topology

Extracellular: 29-159
Helical: 160-180
Cytoplasmic: 181-229

PTM

Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Cheng, G. F., Kong, W. G., Zhai, X., Mu, Q. J., Dong, Z. R., Zhan, M. T., & Xu, Z. (2021). Molecular cloning and expression analysis of CD79a and CD79b in rainbow trout (Oncorhynchus mykiss) after bacterial, parasitic, and viral infection. Fish & Shellfish Immunology, 118, 385-395.

Camus, V., & Tilly, H. (2020). Polatuzumab vedotin, an anti-CD79b antibody–drug conjugate for the treatment of relapsed/refractory diffuse large B-cell lymphoma. Future Oncology, 17(2), 127-135.

Bourbon, E., & Salles, G. (2020). Polatuzumab vedotin: an investigational anti-CD79b antibody drug conjugate for the treatment of diffuse large B-cell lymphoma. Expert Opinion on Investigational Drugs, 29(10), 1079-1088.

Ding, S., Mao, X., Cao, Y., Wang, N., Xu, H., & Zhou, J. (2020). Targeting CD79b for chimeric antigen receptor T-cell therapy of B-cell lymphomas. Targeted Oncology, 15, 365-375.

Li, D., Lee, D., Dere, R. C., Zheng, B., Yu, S. F., Fuh, F. K., ... & Prabhu, S. (2019). Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin. British journal of pharmacology, 176(19), 3805-3818.

Schrader, A. M., Jansen, P. M., Willemze, R., Vermeer, M. H., Cleton-Jansen, A. M., Somers, S. F., ... & Vermaat, J. S. (2018). High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma. Blood, The Journal of the American Society of Hematology, 131(18), 2086-2089.

Li, H., Li, Y., Zhang, X., Wang, Y., Zhang, W., Wu, X., & Wang, Z. (2017). Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus). Fish physiology and biochemistry, 43(6), 1571-1585.

Chen, W., Shankar, S., Lohr, J., Yao, X. T., Li, H., Chen, X., ... & Wigginton, J. (2017). SAT0027 Immunomodulatory effects of MGD010, a dart® molecule targeting human B-CELL CD32B and CD79B.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant CD79B protein, PE Conjugated, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD79B protein, ECD, His Tag (CAT#: V2LY-0526-LY1692)

Human Recombinant CD79B protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2948)

Human Recombinant CD79B protein, ECD, His Tag (CAT#: V2LY-0526-LY2949)

Human Recombinant CD79B protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2950)

Mouse Recombinant CD79B protein, His Tag (CAT#: V2LY-0526-LY8070)

Rat Recombinant CD79B protein, hFc Tag (CAT#: V2LY-0526-LY9268)

Rat Recombinant CD79B protein, His Tag (CAT#: V2LY-0526-LY9269)

CD79B Matched Antibody Pair (235) (CAT#: APMAB-235LY)

Antibody Pairs

CD79B Matched Antibody Pair (235) (CAT#: APMAB-235LY)

Related Products

Mouse Anti-CD79B Recombinant Antibody (C0416) (CAT#: CBMAB-C0416-CQ)

Mouse Anti-CD79B Recombinant Antibody (CBT2188) (CAT#: V2LY-0625-LY1940)

Rat Anti-CD79B Recombinant Antibody (CBFYC-1425) (CAT#: CBMAB-C1483-FY)

Armenian Hamster Anti-CD79B Recombinant Antibody (CBFYC-1426) (CAT#: CBMAB-C1484-FY)

Mouse Anti-CD79B Recombinant Antibody (4E10-2A10) (CAT#: CBMAB-C6834-LY)

Mouse Anti-CD79B Recombinant Antibody (CBXC-1283) (CAT#: CBMAB-C1550-CQ)

Mouse Anti-CD79B Recombinant Antibody (CBYY-C0512) (CAT#: CBMAB-C1530-YY)

Human Recombinant CD79B protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2948)

Mouse Recombinant CD79B protein, His Tag (CAT#: V2LY-0526-LY8070)

Mouse Anti-CD79B Recombinant Antibody (CBYY-C0438) (CAT#: CBMAB-C1394-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry