Human CELSR2 ELISA Kit (V2LY-0626-LY3015)

Name: Human CELSR2 ELISA Kit
SKU: V2LY-0626-LY3015
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0072 ng/mL

Detection Range

0.015-3 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

317.5 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Cadherin EGF LAG Seven-Pass G-Type Receptor 2

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Biological Process

Cell-cell adhesion Source: GO_Central
Cerebrospinal fluid secretion Source: Ensembl
Cilium assembly Source: Ensembl
Cilium movement Source: Ensembl
Dendrite morphogenesis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Neural plate anterior/posterior regionalization Source: BHF-UCL
Neuron migration Source: Ensembl
Regulation of cell-cell adhesion Source: BHF-UCL
Regulation of protein localization Source: Ensembl
Regulation of transcription, DNA-templated Source: BHF-UCL
Ventricular system development Source: Ensembl
Wnt signaling pathway Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 32-2380
Helical: 2381-2401
Cytoplasmic: 2402-2416
Helical: 2417-2437
Extracellular: 2438
Helical: 2439-2459
Cytoplasmic: 2460-2480
Helical: 2481-2501
Extracellular: 2502-2519
Helical: 2520-2540
Cytoplasmic: 2541-2560
Helical: 2561-2581
Extracellular: 2582-2591
Helical: 2592-2612
Cytoplasmic: 2613-2923

PTM

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Tan, J., Che, Y., Liu, Y., Hu, J., Wang, W., Hu, L., ... & Li, J. (2021). CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level. The FASEB Journal, 35(10), e21908.

Xu, M., Zhu, S., Xu, R., & Lin, N. (2020). Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma. BMC cancer, 20(1), 1-15.

Zhou, X., Zhan, Z., Tang, C., Li, J., Zheng, X., Zhu, S., & Qi, J. (2020). Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/β-catenin signaling pathway. Biochemical and Biophysical Research Communications, 533(4), 623-630.

Einarsdottir, E., Grauers, A., Wang, J., Jiao, H., Escher, S. A., Danielsson, A., ... & Gerdhem, P. (2017). CELSR2 is a candidate susceptibility gene in idiopathic scoliosis. PloS one, 12(12), e0189591.

Goffinet, A. M., & Tissir, F. (2017, September). Seven pass cadherins CELSR1-3. In Seminars in cell & developmental biology (Vol. 69, pp. 102-110). Academic Press.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-CELSR2 Recombinant Antibody (CP0278) (CAT#: CBMAB-CP0278-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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