Human DAB1 ELISA Kit (V2LY-0626-LY3332)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0074 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
63.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
DAB1, Reelin Adaptor Protein
Function
Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Biological Process
Adult walking behavior Source: Ensembl
Axon guidance Source: Reactome
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Source: Ensembl
Cerebellum structural organization Source: Ensembl
Dendrite development Source: Ensembl
Golgi localization Source: Ensembl
Hippocampus development Source: Ensembl
Lateral motor column neuron migration Source: GO_Central
Midgut development Source: Ensembl
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of axonogenesis Source: Ensembl
Negative regulation of cell adhesion Source: Ensembl
Negative regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of protein kinase activity Source: Ensembl
Radial glia guided migration of Purkinje cell Source: Ensembl
Response to drug Source: Ensembl
Small GTPase mediated signal transduction Source: Ensembl
Ventral spinal cord development Source: GO_Central
Cellular Location
Cytosol; Apical part of cell; Brush border; Cytoplasm; Intracellular membrane-bounded organelle; Membrane; Neuron projection; Neuronal cell body; Perinuclear region of cytoplasm; Postsynaptic density
Involvement in disease
Spinocerebellar ataxia 37 (SCA37):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA37 is an autosomal dominant form characterized by adult-onset of slowly progressive gait instability, frequent falls, and dysarthria associated with cerebellar atrophy on brain imaging.
PTM
Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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