Human ADRA2B ELISA Kit (V2LY-0626-LY5592)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.017 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
50.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Adrenoceptor Alpha 2B
Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine> norepinephrine> epinephrine = oxymetazoline> dopamine> p-tyramine = phenylephrine> serotonin> p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine> chlorpromazine> phentolamine> mianserine> spiperone> prazosin> alprenolol> propanolol> pindolol.
Biological Process
Activation of MAPK activity
Activation of protein kinase B activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adrenergic receptor signaling pathway
Cell-cell signaling
Female pregnancy
G protein-coupled receptor signaling pathway
Negative regulation of epinephrine secretion
Negative regulation of norepinephrine secretion
Platelet activation
Positive regulation of blood pressure
Positive regulation of MAPK cascade
Positive regulation of neuron differentiation
Positive regulation of uterine smooth muscle contraction
Receptor transactivation
Regulation of vascular associated smooth muscle contraction
Cellular Location
Cell membrane. Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane.
Involvement in disease
Epilepsy, familial adult myoclonic, 2 (FAME2): A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant.
Topology
Extracellular: 1-12 aa
Helical: 13-38 aa
Cytoplasmic: 39-48 aa
Helical: 49-69 aa
Extracellular: 70-86 aa
Helical: 87-107 aa
Cytoplasmic: 108-128 aa
Helical: 129-149 aa
Extracellular: 150-172 aa
Helical: 173-193 aa
Cytoplasmic: 194-368 aa
Helical: 369-389 aa
Extracellular: 390-405 aa
Helical: 406-426 aa
Cytoplasmic: 427-450 aa

Rao, X., Asico, L. D., Zanos, P., Mahabeleshwar, G. H., Singh Gangwar, R., Xia, C., ... & Rajagopalan, S. (2019). Alpha2B-adrenergic receptor overexpression in the brain potentiate air pollution-induced behavior and blood pressure changes. Toxicological Sciences, 169(1), 95-107.

Melnikov, V. N., Baranov, V. I., Suvorova, I. Y., & Krivoschekov, S. G. (2018). Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population. Physiological genomics, 50(2), 100-101.

Xie, W., Cappiello, M., Meng, M., Rosenthal, R., & Zhang, W. (2018). ADRA2B deletion variant and enhanced cognitive processing of emotional information: A meta-analytical review. Neuroscience & Biobehavioral Reviews, 92, 402-416.

Wirz, L., Wacker, J., Felten, A., Reuter, M., & Schwabe, L. (2017). A deletion variant of the α2b-adrenoceptor modulates the stress-induced shift from “cognitive” to “habit” memory. Journal of Neuroscience, 37(8), 2149-2160.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ADRA2B Recombinant Antibody (V2-180022) (CAT#: CBMAB-A1415-YC)

Isotype control

For research use only. Not intended for any clinical use.

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