Human GM2A ELISA Kit (2) (V2LY-0626-LY4607)

Name: Human GM2A ELISA Kit (2)
SKU: V2LY-0626-LY4607
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0053 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

20.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

GM2 Ganglioside Activator

Function

The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity).

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity).

Has cholesterol transfer activity (PubMed:17552909).

Biological Process

Ganglioside catabolic process Source: GO_Central
Glycosphingolipid metabolic process Source: Reactome
Learning or memory Source: Ensembl
Lipid storage Source: Ensembl
Lipid transport Source: GO_Central
Neuromuscular process controlling balance Source: Ensembl
Oligosaccharide catabolic process Source: Ensembl
Positive regulation of hydrolase activity Source: Ensembl

Cellular Location

Lysosome

Involvement in disease

GM2-gangliosidosis AB (GM2GAB):
An autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. It is characterized by GM2 gangliosides accumulation in the presence of both normal hexosaminidase A and B.

PTM

The serines in positions 32 and 33 are absent in 80% of the sequenced protein.

Hsieh, Y. C., Negri, J., He, A., Pearse, R. V., Liu, L., Duong, D. M., ... & Young-Pearse, T. L. (2022). Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. Molecular neurodegeneration, 17(1), 61.

Xiao, C., Toro, C., & Tifft, C. (2022). GM2 Activator Deficiency. GeneReviews®[Internet].

Kafaei Shahbaz, N. (2022). The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway (Doctoral dissertation).

Yuan, J., Li, Z., Lin, Z., Yao, S., Han, Y., Fu, Q., & Liu, J. (2022). Label-free quantitative proteomics reveals the Steap3-Gm2a axis inhibiting the phagosomal escape of Listeria monocytogenes. Microbes and Infection, 24(8), 104999.

Beeler, K., Vowinckel, J., Soste, M., Mallardo, D., Capone, M., Gabriele, M., ... & Ascierto, P. (2020). 229 Discovery of ganglioside GM2 activator as a novel proteomic biomarker associated with response to treatment in first-line melanoma subjects treated with PD-1 immunotherapy.

Holzer, K., Drucker, E., Waldburger, N., Eiteneuer, E., Breuhahn, K., Ori, A., ... & Singer, S. (2018). Ganglioside GM2 activator (GM2A) is as a novel pro-survival p53 target in hepatocellular carcinoma. Zeitschrift für Gastroenterologie, 56(01), A4-44.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant GM2A protein, His Tag (CAT#: V2LY-0526-LY4356)

Human GM2A ELISA Kit (CAT#: V2LY-0626-LY3115)

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Mouse Anti-GM2A Recombinant Antibody (CF186) (CAT#: CBMAB-FT297LY)

Mouse Anti-GM2A Recombinant Antibody (CBLG1-1353) (CAT#: V2LY-0226-LY64)

Mouse Anti-GM2A Recombinant Antibody (CBLG1-1351) (CAT#: CBMAB-G3993-LY)

Human Recombinant GM2A protein, His Tag (CAT#: V2LY-0526-LY4356)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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